Expression of dominant negative Jun inhibits elevated AP-1 and NF-κB transactivation and suppresses anchorage independent growth of HPV immortalized human …
JJ Li, JS Rhim, R Schlegel, KH Vousden, NH Colburn - Oncogene, 1998 - nature.com
AP-1 transactivation appears to be required for mouse JB6 cell neoplastic transformation
induced by the tumor promoter TPA or epidermal growth factor (EGF). Exposure to AP-1 …
induced by the tumor promoter TPA or epidermal growth factor (EGF). Exposure to AP-1 …
Induced expression of dominant‐negative c‐jun downregulates NFκB and AP‐1 target genes and suppresses tumor phenotype in human keratinocytes
Neoplastically transformed mouse and human keratinocytes elevate transactivation of both
activator protein 1 (AP‐1) and nuclear factor κB (NFκB) transcription factors. The present …
activator protein 1 (AP‐1) and nuclear factor κB (NFκB) transcription factors. The present …
Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion
Activator protein-1 (AP-1) is a transcription factor that consists of either a Jun-Jun
homodimer or a Jun-Fos heterodimer. Transactivation of AP-1 is required for tumor promoter …
homodimer or a Jun-Fos heterodimer. Transactivation of AP-1 is required for tumor promoter …
A dominant negative mutant of jun blocking 12‐O‐tetradecanoylphorbol‐13‐acetate–induced invasion in mouse keratinocytes
Z Dong, HC Crawford, V Lavrovsky… - … in cooperation with …, 1997 - Wiley Online Library
We previously reported that induced activator protein‐1 (AP‐1) transcriptional activity
appears to be required for tumor promoter–induced transformation in mouse epidermal JB6 …
appears to be required for tumor promoter–induced transformation in mouse epidermal JB6 …
Progressive elevation of AP-1 activity during preneoplastic-to-neoplastic progression as modeled in mouse JB6 cell variants
The JB6 mouse epidermal cell system has been used extensively as an in vitro model for the
study of tumor promotion and progression. The present study was directed to assessing the …
study of tumor promotion and progression. The present study was directed to assessing the …
Inhibition of AP-1 suppresses cervical cancer cell proliferation and is associated with p21 expression
MF Maritz, PJ van der Watt, N Holderness, MJ Birrer… - 2011 - degruyter.com
AP-1, a transcription factor comprised primarily of Jun and Fos family proteins, regulates
genes involved in proliferation, differentiation and oncogenesis. Previous studies …
genes involved in proliferation, differentiation and oncogenesis. Previous studies …
Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells.
AP-1 transcriptional activity is stimulated by the transformation promoters phorbol 12-
myristate 13-acetate (" 12-O-tetradecanoylphorbol 13-acetate," TPA) and epidermal growth …
myristate 13-acetate (" 12-O-tetradecanoylphorbol 13-acetate," TPA) and epidermal growth …
Conversion of HPV 18 positive non-tumorigenic HeLa-fibroblast hybrids to invasive growth involves loss of TNF-α mediated repression of viral transcription and …
AP-1 represents a transcription factor, which plays a pivotal role in initiating and maintaining
the expression of human papillomavirus (HPV) oncoproteins E6 and E7 during HPV-linked …
the expression of human papillomavirus (HPV) oncoproteins E6 and E7 during HPV-linked …
AP-1 activity during normal human keratinocyte differentiation: evidence for a cytosolic modulator of AP-1/DNA binding
P Briata, F D'Anna, AT Franzi, R Gherzi - Experimental cell research, 1993 - Elsevier
Increased levels of c-fos and c-jun expression have been observed in differentiating
epithelial cells. However, no data are available on activator protein 1 (AP-1) activity during …
epithelial cells. However, no data are available on activator protein 1 (AP-1) activity during …
Differential c‐jun expression in response to tumor promoters in JB6 cells sensitive or resistant to neoplastic transformation
ET Ben‐Ari, LR Bernstein… - Molecular …, 1992 - Wiley Online Library
The activity of AP‐1, a trans‐acting transcription factor, is stimulated by 12‐O‐
tetradecanoylphorbol‐13‐acetate (TPA) and epidermal growth factor (EGF) in promotion …
tetradecanoylphorbol‐13‐acetate (TPA) and epidermal growth factor (EGF) in promotion …