Apoptosis and pharmacological therapies for targeting thereof for cancer therapeutics

V Singh, A Khurana, U Navik, P Allawadhi, KK Bharani… - Sci, 2022 - mdpi.com
Apoptosis is an evolutionarily conserved sequential process of cell death to maintain a
homeostatic balance between cell formation and cell death. It is a vital process for normal …

Potential of apoptotic pathway-targeted cancer therapeutic research: Where do we stand?

S Baig, I Seevasant, J Mohamad, A Mukheem… - Cell death & …, 2016 - nature.com
Underneath the intricacy of every cancer lies mysterious events that impel the tumour cell
and its posterity into abnormal growth and tissue invasion. Oncogenic mutations disturb the …

Apoptotic pathways in tumor progression and therapy

R Khosravi-Far, E White, A Melet, K Song… - Programmed cell death …, 2008 - Springer
Apoptosis is a cell suicide program that plays a critical role in development and tissue
homeostasis. The ability of cancer cells to evade this programmed cell death (PCD) is a …

Targeting apoptosis in cancer therapy

BA Carneiro, WS El-Deiry - Nature reviews Clinical oncology, 2020 - nature.com
For over three decades, a mainstay and goal of clinical oncology has been the development
of therapies promoting the effective elimination of cancer cells by apoptosis. This …

[HTML][HTML] Understanding apoptosis and apoptotic pathways targeted cancer therapeutics

R Jan - Advanced pharmaceutical bulletin, 2019 - ncbi.nlm.nih.gov
Various physiological processes involve appropriate tissue developmental process and
homeostasis-the pathogenesis of several diseases connected with deregulatory apoptosis …

Apoptosis and cancer: force awakens, phantom menace, or both?

K Cao, SWG Tait - International review of cell and molecular biology, 2018 - Elsevier
Apoptotic cell death serves as an important tumor suppressor mechanism at multiple steps
during cancer progression. Equally, engagement of apoptosis represents a potent …

[HTML][HTML] Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies

G Pistritto, D Trisciuoglio, C Ceci, A Garufi… - Aging (albany …, 2016 - ncbi.nlm.nih.gov
Apoptosis is a form of programmed cell death that results in the orderly and efficient removal
of damaged cells, such as those resulting from DNA damage or during development …

Dysregulation of apoptotic signaling in cancer: molecular mechanisms and therapeutic opportunities

J Plati, O Bucur, R Khosravi‐Far - Journal of cellular …, 2008 - Wiley Online Library
Apoptosis is a tightly regulated cell suicide program that plays an essential role in the
maintenance of tissue homeostasis by eliminating unnecessary or harmful cells. Defects in …

Apoptosis regulators as targets for cancer therapy

JL Fernandez-Luna - Clinical and translational oncology, 2007 - Springer
Apoptosis serves to remove excess or damaged cells and its dysregulation may lead to a
number of pathological disorders including cancer. Studies during the last 20 years have …

Apoptosis—molecular mechanisms and biomedical implications

DJ McConkey, B Zhivotovsky, S Orrenius - Molecular aspects of medicine, 1996 - Elsevier
Apoptosis is a distinct form of cell death of importance in tissue development and
homeostasis and in several diseases. This review summarizes current knowledge about the …