Understanding the impact of cytokine gene polymorphisms (IL10 rs1800872 and TNF rs1800629) on COVID-19 severity: A comprehensive meta-analysis

S Velmurugan, R Pauline, L Kulanthaivel, GK Subbaraj - Human Gene, 2024 - Elsevier
Aim The anti-inflammatory and pro-inflammatory cytokine genes are linked to the severity
and prognosis of individuals with respiratory and non-respiratory viral infections. The …

Association of Interleukin-6 (rs1800795) and Interleukin-10 (rs1800896) Genetic Polymorphisms with the Outcome of COVID-19 Infection: A Single Center Study

M El-Bendary, M Naemattalah, H Elalfy… - Viral …, 2024 - liebertpub.com
The corona virus disease-2019 (COVID-19) pandemic has affected most of the world with
varying degrees of morbidity and mortality. The presence of genetic polymorphisms may be …

Single nucleotide polymorphisms located in TNFA, IL1RN, IL6R, and IL6 genes are associated with COVID‐19 risk and severity in an Iranian population

M Rokni, M Sarhadi, M Heidari Nia… - Cell Biology …, 2022 - Wiley Online Library
Cytokines play pivotal functions in coronavirus disease 2019 (COVID‐19) pathogenesis.
However, little is known about the rationale and importance of genetic variations associated …

Association between interleukin-10 gene polymorphisms (rs1800871, rs1800872, and rs1800896) and severity of infection in different SARS-CoV-2 variants

SJA Abbood, E Anvari, A Fateh - Human Genomics, 2023 - Springer
Background Polymorphisms in the interleukin-10 (IL10) gene have been linked to the
severity of the patients infected with the viral infections. This study aimed to assess if the …

Evaluation of the relationship between IL-6 gene single nucleotide polymorphisms and the severity of COVID-19 in an Iranian population

S Falahi, MH Zamanian, P Feizollahi, A Rezaiemanesh… - Cytokine, 2022 - Elsevier
Background Emerged coronavirus disease 2019 (COVID-19) is a pandemic caused by the
severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). Disease severity is …

Correlation between interleukin gene polymorphisms and current prevalence and mortality rates due to novel coronavirus disease 2019 (COVID‐2019) in 23 countries

L Karcioglu Batur, N Hekim - Journal of Medical Virology, 2021 - Wiley Online Library
Background The novel coronavirus disease 2019 (COVID‐19) infection may rely on a
potential genetic background for the variations in the inflammatory response. We aimed to …

Impact of interleukin-1 gene polymorphisms on the severity of COVID-19

S Verma, S Verma, S Afreen, Z Siddiqi, FH Khan… - Human Gene, 2024 - Elsevier
Abstract The severity of Coronavirus Disease 2019 (COVID-19) has been closely linked to
an exacerbated proinflammatory response and cytokine storm. Interleukin-1 (IL-1), a pivotal …

Genetic polymorphisms of IL6 gene–174G> C and–597G> A are associated with the risk of COVID‐19 severity

S Verma, S Verma, FH Khan, Z Siddiqi… - International Journal …, 2023 - Wiley Online Library
Abstract Coronavirus disease‐2019 (COVID‐19) is pro‐inflammatory disorder characterized
by acute respiratory distress syndrome. Interleukin‐6, a cytokine secreted by macrophages …

Influence of IL-6 rs1800795 and IL-8 rs2227306 polymorphisms on COVID-19 outcome

AA Ghazy - The Journal of Infection in Developing Countries, 2023 - jidc.org
Introduction: Severe coronavirus disease 2019 (COVID-19) is mainly precipitated by an
uncontrolled inflammatory response and cytokine storm. Pro-inflammatory cytokines such as …

Implication of single nucleotide polymorphisms in Interleukin-10 gene (rs1800896 and rs1800872) with severity of COVID-19

S Rizvi, SMS Rizvi, ST Raza, M Abbas, K Fatima… - Egyptian Journal of …, 2022 - Springer
Abstract Background Coronavirus disease 2019 (COVID-19) is an ongoing pandemic which
has emerged as a new challenge for the medical sciences. Severity of COVID-19 is mostly …