Breast Cancer Susceptibility Gene 1 (BRCA1) plays a crucial role in the homologous
recombination (HR) pathway to repair double-stranded breaks (DSBs) in human cells …

Homologous recombination (HR) is a faithful mechanism for the repair of double-stranded
DNA breaks (DSBs) and plays a critical role in maintaining the integrity of genomic DNA …

BRCA2 tumour-suppressor protein is well known for its role in DNA repair by homologous
recombination (HR); assisting the loading of RAD51 recombinase at DNA double-strand …

Breast cancer type two susceptibility protein (BRCA2) is an essential protein in genome
maintenance, homologous recombination (HR), and replication fork protection. Its function …

Mutations of the breast cancer susceptibility 1 (BRCA1) gene are associated with high risks
of breast and ovarian cancer, not least due to the vital role of the BRCA1 gene product in …

BRCA2 tumor suppressor protein ensures genome integrity by mediating DNA repair via
homologous recombination (HR). This function is executed in part by its canonical DNA …

DNA double-strand breaks (DSBs) occur in response to both endogenous and exogenous
genotoxic stress. Inappropriate repair of DSBs can lead to either loss of viability or to …

Loss-of-function mutations in BRCA1 confer a predisposition to breast and ovarian cancer.
Genetic testing for mutations in the BRCA1 gene frequently reveals a missense variant for …

Mutations in the BRCA2 (breast cancer susceptibility gene 2) tumor suppressor lead to
chromosomal instability due to defects in the repair of double-strand DNA breaks (DSBs) by …

BRCA1 is the first susceptibility gene to be linked to breast and ovarian cancers. Although
mounting evidence has indicated that BRCA1 participates in DNA double-strand break …