[HTML][HTML] Recent advances in targeted drug delivery strategy for enhancing oncotherapy

J Li, Q Wang, G Xia, N Adilijiang, Y Li, Z Hou, Z Fan… - Pharmaceutics, 2023 - mdpi.com
Targeted drug delivery is a precise and effective strategy in oncotherapy that can accurately
deliver drugs to tumor cells or tissues to enhance their therapeutic effect and, meanwhile …

Receptor-based targeting of engineered nanocarrier against solid tumors: Recent progress and challenges ahead

MH Akhter, S Beg, M Tarique, A Malik, S Afaq… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Background In past few decades, the research on engineered nanocarriers (NCs) has
gained significant attention in cancer therapy due to selective delivery of drug molecules on …

Actively targeted nanoparticles for drug delivery to tumor

Y Bi, F Hao, G Yan, L Teng, RJ Lee… - Current drug …, 2016 - ingentaconnect.com
Background: Nanomedicine is an emerging therapeutic modality. Nanoparticles (NPs) are
potential vehicles for delivery of anticancer therapeutics. NPs can be designed to facilitate …

Design of nanocarriers based on complex biological barriers in vivo for tumor therapy

J Liu, M Li, Z Luo, L Dai, X Guo, K Cai - Nano Today, 2017 - Elsevier
Nanoscale drug delivery systems (NDDS) have shown great potential in tumor treatment
due to its unique advantages, especially its unique enhanced permeability and retention …

Strategies to enhance drug delivery to solid tumors by harnessing the EPR effects and alternative targeting mechanisms

Y Zi, K Yang, J He, Z Wu, J Liu, W Zhang - Advanced Drug Delivery …, 2022 - Elsevier
Abstract The Enhanced Permeability and Retention (EPR) effect has been recognized as the
central paradigm in tumor-targeted delivery in the last decades. In the wake of this concept …

Extracellularly activated nanocarriers: a new paradigm of tumor targeted drug delivery

E Gullotti, Y Yeo - Molecular pharmaceutics, 2009 - ACS Publications
One of the main goals of nanomedicine is to develop a nanocarrier that can selectively
deliver anticancer drugs to the targeted tumors. Extensive efforts have resulted in several …

Enhanced permeability and retention effect for selective targeting of anticancer nanomedicine: are we there yet?

K Greish - Drug Discovery Today: Technologies, 2012 - Elsevier
Enhanced permeability and retention (EPR) effect is a popular strategy for targeting
nanosize anticancer drugs to tumor tissues. In this review we discuss how EPR effect …

Recent advances in drug delivery systems for enhancing drug penetration into tumors

B He, X Sui, B Yu, S Wang, Y Shen, H Cong - Drug delivery, 2020 - Taylor & Francis
The emergence of nanomaterials for drug delivery provides the opportunity to avoid the side
effects of systemic drug administration and injury caused by the removal of tumors …

[HTML][HTML] Approaches to improve macromolecule and nanoparticle accumulation in the tumor microenvironment by the enhanced permeability and retention effect

V Ejigah, O Owoseni, P Bataille-Backer, OD Ogundipe… - Polymers, 2022 - mdpi.com
Passive targeting is the foremost mechanism by which nanocarriers and drug-bearing
macromolecules deliver their payload selectively to solid tumors. An important driver of …

[HTML][HTML] An updated review on EPR-based solid tumor targeting nanocarriers for cancer treatment

M Sharifi, WC Cho, A Ansariesfahani, R Tarharoudi… - Cancers, 2022 - mdpi.com
Simple Summary One of the important efforts in the treatment of cancers is to achieve
targeted drug delivery by nanocarriers to be more effective and reduce adverse effects …