Immune system targeting by biodegradable nanoparticles for cancer vaccines

JM Silva, M Videira, R Gaspar, V Préat… - Journal of controlled …, 2013 - Elsevier
The concept of therapeutic cancer vaccines is based on the activation of the immune system
against tumor cells after the presentation of tumor antigens. Nanoparticles (NPs) have …

Targeting dendritic cells with nano-particulate PLGA cancer vaccine formulations

S Hamdy, A Haddadi, RW Hung… - Advanced drug delivery …, 2011 - Elsevier
Development of safe and effective cancer vaccine formulation is a primary focus in the field
of cancer immunotherapy. The recognition of the crucial role of dendritic cells (DCs) in …

Harnessing Dendritic Cells for Poly (D,L-lactide-co-glycolide) Microspheres (PLGA MS)—Mediated Anti-tumor Therapy

J Koerner, D Horvath, M Groettrup - Frontiers in immunology, 2019 - frontiersin.org
With emerging success in fighting off cancer, chronic infections, and autoimmune diseases,
immunotherapy has become a promising therapeutic approach compared to conventional …

Biodegradable nanoparticles as vaccine adjuvants and delivery systems: regulation of immune responses by nanoparticle-based vaccine

T Akagi, M Baba, M Akashi - Polymers in nanomedicine, 2012 - Springer
Polymeric nano-and microparticles have recently been shown to possess significant
potential as drug delivery systems. In particular, the use of biodegradable polymeric …

Polymer nanoparticles containing tumor lysates as antigen delivery vehicles for dendritic cell–based antitumor immunotherapy

S Prasad, V Cody, JK Saucier-Sawyer… - … , Biology and Medicine, 2011 - Elsevier
Encapsulation of tumor-associated antigens in polymer nanoparticles (NP) is a promising
approach to enhance efficiency of antigen delivery for anti-tumor vaccines. Head and neck …

Poly (d, l-lactide-co-glycolide) nanoparticles as delivery platforms for TLR7/8 agonist-based cancer vaccine

H Kim, TS Griffith, J Panyam - Journal of Pharmacology and Experimental …, 2019 - ASPET
Targeted drug delivery can significantly influence the efficacy of a drug. In the past decades,
diverse drug-delivery technologies, including nano-and microparticles, co-crystals, and …

Biodegradable polymeric nanoparticles-based vaccine adjuvants for lymph nodes targeting

A Gutjahr, C Phelip, AL Coolen, C Monge, AS Boisgard… - Vaccines, 2016 - mdpi.com
Vaccines have successfully eradicated a large number of diseases. However, some
infectious diseases (such as HIV, Chlamydia trachomatis or Bacillus anthracis) keep …

Targeting human dendritic cells via DEC-205 using PLGA nanoparticles leads to enhanced cross-presentation of a melanoma-associated antigen

SS Saluja, DJ Hanlon, FA Sharp, E Hong… - International journal …, 2014 - Taylor & Francis
Targeting antigen to dendritic cells (DCs) is a powerful and novel strategy for vaccination.
Priming or loading DCs with antigen controls whether subsequent immunity will develop and …

Polymeric nanoparticles: potent vectors for vaccine delivery targeting cancer and infectious diseases

A Bolhassani, S Javanzad, T Saleh… - Human vaccines & …, 2014 - Taylor & Francis
Nanocarriers with various compositions and biological properties have been extensively
applied for in vitro/in vivo drug and gene delivery. The family of nanocarriers includes …

Nanoparticles to improve the efficacy of peptide-based cancer vaccines

AL Tornesello, M Tagliamonte, ML Tornesello… - Cancers, 2020 - mdpi.com
Nanoparticles represent a potent antigen presentation and delivery system to elicit an
optimal immune response by effector cells targeting tumor-associated antigens expressed …