Inflammation and inflammasomes have been proposed as important regulators of the host–
microorganism interaction, playing a key role in morbidity and mortality due to the …

The nucleotide-binding domain (NOD)-, leucine-rich repeat (LRR)-, and pyrin domain (PYD)-
containing protein 3, NLRP3, is a multiprotein complex belonging to the innate immune …

Cardiovascular disease is a major cause of death worldwide. Inflammasome infiltration has
been identified to play a central role in the pathological progression of certain …

Cardiovascular diseases (CVDs) are the prevalent cause of mortality around the world.
Activation of inflammasome contributes to the pathological progression of cardiovascular …

NLRP3 is the best characterized cytosolic nod-like pattern recognition receptor which can
detect microbial motifs, endogenous danger and stress signals. Activation of NLRP3 leads to …

Innate immune cells rely on pathogen recognition receptors such as the nucleotide-binding
and oligomerization domain (NOD)-like receptor (NLR) family to mount an appropriate …

The nod-like receptor family pyrin domain containing 3 (NLRP3) is currently the most widely
studied inflammasome and has become a hot topic of recent research. As a macromolecular …

Inflammation is a protective reaction activated in response to detrimental stimuli, such as
dead cells, irritants or pathogens, by the evolutionarily conserved immune system and is …

The NLRP3 inflammasome is an important part of the body's innate immune system, and a
multiprotein platform which is activated by recognizing pathogen-associated molecular …

The NLRP3 inflammasome is a critical component of the innate immune system that
mediates caspase-1 activation and the secretion of proinflammatory cytokines IL-1β/IL-18 in …