Middle age has historically been an understudied period of life compared to older age, when
cognitive and brain health decline are most pronounced, but the scope for intervention may …

As cognitive neuroscientists have learned more about neural and cognitive function across
the lifespan, understanding the developmental phase of middle age has taken on new …

Brain age is a widely used index for quantifying individuals' brain health as deviation from a
normative brain aging trajectory. Higher-than-expected brain age is thought partially to …

The search for reliable early indicators of age-related cognitive decline represents a critical
avenue for progress in aging research. Chronological age is a commonly used …

The concept of brain maintenance refers to the preservation of brain integrity in older age,
while cognitive reserve refers to the capacity to maintain cognition in the presence of …

The healthy adult brain undergoes tissue volume decline with age, but contradictory findings
abound regarding rate of change. To identify a source of this discrepancy, we present …

Many neuroimaging studies of age-related memory decline interpret resultant differences in
brain activation patterns in the elderly as reflecting a type of compensatory response or …

An individual's brainAGE is the difference between chronological age and age predicted
from machine-learning models of brain-imaging data. BrainAGE has been proposed as a …

Cross-sectional neuroimaging studies suggest that hippocampal and prefrontal cortex
functions underlie individual differences in memory ability in older individuals, but it is …

While aging is associated with modest declines in certain aspects of cognitive function
(memory, executive function, processing speed), many cognitive domains can remain …