Principles of mitoribosomal small subunit assembly in eukaryotes

NJ Harper, C Burnside, S Klinge - Nature, 2023 - nature.com
Mitochondrial ribosomes (mitoribosomes) synthesize proteins encoded within the
mitochondrial genome that are assembled into oxidative phosphorylation complexes. Thus …

Structures of the human mitochondrial ribosome in native states of assembly

A Brown, S Rathore, D Kimanius, S Aibara… - Nature structural & …, 2017 - nature.com
Mammalian mitochondrial ribosomes (mitoribosomes) have less rRNA content and 36
additional proteins compared with the evolutionarily related bacterial ribosome. These …

[HTML][HTML] Mechanism of mitoribosomal small subunit biogenesis and preinitiation

Y Itoh, A Khawaja, I Laptev, M Cipullo, I Atanassov… - Nature, 2022 - nature.com
Mitoribosomes are essential for the synthesis and maintenance of bioenergetic proteins.
Here we use cryo-electron microscopy to determine a series of the small mitoribosomal …

Mitoribosomal small subunit biogenesis in trypanosomes involves an extensive assembly machinery

M Saurer, DJF Ramrath, M Niemann, S Calderaro… - Science, 2019 - science.org
Mitochondrial ribosomes (mitoribosomes) are large ribonucleoprotein complexes that
synthesize proteins encoded by the mitochondrial genome. An extensive cellular machinery …

The complete structure of the large subunit of the mammalian mitochondrial ribosome

BJ Greber, D Boehringer, M Leibundgut, P Bieri… - Nature, 2014 - nature.com
Mitochondrial ribosomes (mitoribosomes) are extensively modified ribosomes of bacterial
descent specialized for the synthesis and insertion of membrane proteins that are critical for …

Structural basis for late maturation steps of the human mitoribosomal large subunit

M Cipullo, GV Gesé, A Khawaja, BM Hällberg… - Nature …, 2021 - nature.com
Mitochondrial ribosomes (mitoribosomes) synthesize a critical set of proteins essential for
oxidative phosphorylation. Therefore, mitoribosomal function is vital to the cellular energy …

Architecture of the large subunit of the mammalian mitochondrial ribosome

BJ Greber, D Boehringer, A Leitner, P Bieri… - Nature, 2014 - nature.com
Mitochondrial ribosomes synthesize a number of highly hydrophobic proteins encoded on
the genome of mitochondria, the organelles in eukaryotic cells that are responsible for …

Mitoribosomal small subunit maturation involves formation of initiation-like complexes

T Lenarčič, M Niemann, DJF Ramrath… - Proceedings of the …, 2022 - National Acad Sciences
Mitochondrial ribosomes (mitoribosomes) play a central role in synthesizing mitochondrial
inner membrane proteins responsible for oxidative phosphorylation. Although …

Yeast mitoribosome large subunit assembly proceeds by hierarchical incorporation of protein clusters and modules on the inner membrane

R Zeng, E Smith, A Barrientos - Cell metabolism, 2018 - cell.com
Mitoribosomes are specialized for the synthesis of hydrophobic membrane proteins
encoded by mtDNA, all essential for oxidative phosphorylation. Despite their linkage to …

The structure of the yeast mitochondrial ribosome

N Desai, A Brown, A Amunts, V Ramakrishnan - Science, 2017 - science.org
Mitochondria have specialized ribosomes (mitoribosomes) dedicated to the expression of
the genetic information encoded by their genomes. Here, using electron cryomicroscopy, we …