As it was established that aging is not associated with massive neuronal loss, as was
believed in the mid‐20th Century, scientific interest has addressed the influence of aging on …

Normal ageing is associated with impairments in cognitive function, including memory.
These impairments are linked, not to a loss of neurons in the forebrain, but to specific and …

Several studies using vertebrate and invertebrate animal models have shown aging
associated changes in brain function. Importantly, changes in soma size, loss or regression …

In this review, we focus on the potential role of the γ-aminobutyric acidergic (GABAergic)
system in age-related episodic memory impairments in humans, with a particular focus on …

Aging is associated with impairments in learning and memory and a greater incidence of
limbic seizures. These changes in the aged brain have been associated with increased …

Astrocytes have traditionally been viewed as passive supportive cells, which were primarily
responsible for maintaining an optimal environment for electrical neuronal activity. Recent …

Considering the mechanisms responsible for age-and Alzheimer's disease (AD)-related
neuronal degeneration, little attention was paid to the opposing relationships between the …

What is the neuroanatomical basis for the decline in brain function that occurs during normal
aging? Previous postmortem studies have blamed it on a reduction in spine density, though …

Impaired synaptic plasticity is implicated in the functional decline of the nervous system
associated with ageing. Understanding the structure of ageing synapses is essential to …

Excitatory synaptic transmission is altered during aging in hippocampal granule cells, and in
CA3 and CA1 pyramidal cells. These functional changes contribute to age-associated …