Telomerase is a ribonucleoprotein enzyme that synthesizes telomere end sequence. The
expression of hTERT gene, encoding the catalytic subunit of human telomerase, is restricted …

Human telomerase reverse transcriptase (hTERT) is the catalytic subunit of telomerase,
whose expression is strictly regulated dependently upon cell types. hTERT is shown to be …

Telomerase activation is thought to be a critical step in cellular immortalization and
carcinogenesis. Of the three major subunits comprising human telomerase, human …

Telomerase is a specialized nucleoprotein enzyme complex that maintains the telomere
length. The telomerase reverse transcriptase (TERT) is the catalytically active component of …

Telomerase is a ribonucleoprotein complex, whose function is to add motif-specific
nucleotides to the end of chromosomes. Telomerase consists of three major subunits, the …

Human telomerase reverse transcriptase (hTERT), the catalytic subunit of telomerase in
human, has been identified as the rate-limiting factor in telomerase activity, but its detailed …

Telomerase is a ribonucleoprotein complex of which the function is to add telomeric repeats
to chromosomal ends. Telomerase consists of two essential components, the telomerase …

Telomerase activity and telomere elongation are essential conditions for the unlimited
proliferation of neoplastic cells. Point mutations in the core promoter region of the …

Malignant transformation from mortal, normal cells to immortal, cancer cells is generally
associated with activation of telomerase and subsequent telomere maintenance. A major …

Activation of telomerase is one of the rate-limiting steps in human cell immortalization and
carcinogenesis. Human telomerase is composed of at least two protein subunits and an …