Cisplatin is a potent chemotherapeutic drug that is widely used in the treatment of various
solid cancers. However, its clinical effectiveness is strongly limited by frequent severe …

Oxaliplatin has been used as a first choice for colorectal, gastric and pancreatic cancer, but it
induces peripheral neuropathies. Dimethyl fumarate (DMF) is an oral drug for multiple …

Cisplatin is a chemotherapeutic drug but induces acute kidney injury (AKI). Cisplatin-
induced AKI depends on several signaling pathways leading to apoptosis in tubular …

Context: Currently, the outcomes of the use of cisplatin in cancer therapy is limited by
nephrotoxicity. Objective: This study aims to investigate the nephroprotective role of …

Cisplatin is a platinum-based chemotherapy drug. However, its chemotherapeutic use is
restricted by serious side effects, especially nephrotoxicity. Inflammatory mechanisms have …

Oxaliplatin frequently causes severe peripheral neuropathy as a dose-limiting toxicity.
However, this toxicity lacks a strategy for prevention. Cystine/Theanine is a supplement …

Background The aim of the present study was to evaluate the neuroprotective effect of
allantoin in cisplatin‐induced toxicity in rats. Methods Adult male Wistar rats weighing 160 …

Cisplatin is widely used as an anti-tumor drug for the treatment of solid tumors.
Unfortunately, it causes kidney toxicity as a critical side effect, limiting its use, given that no …

Cisplatin (CDDP) is a well-known anticancer agent, and CDDP–induced nephrotoxicity
(CIN) is one of the most serious adverse effects. Previously, we revealed that while …

Cisplatin is a first-line chemotherapeutic agent that is widely used for treatment of various
solid tumors. However, cisplatin-induced adverse effects, particularly severe nephrotoxicity …