To understand the role of environment in the pathoetiology of psychosis spectrum disorders,
research has thus far mainly investigated the effects of single exposures in isolation, such as …

Previously, we established an estimated exposome score for schizophrenia (ES-SCZ) as a
cumulative measure of environmental liability for schizophrenia to use in gene–environment …

There is an active interest in understanding the relationship between mental disorders and
modifiable and potentially preventable exposures. However, the complexity of the …

Exposures constitute a dense network of the environment: exposome. Here, we argue for
embracing the exposome paradigm to investigate the sum of nongenetic “risk” and show …

Background The exposome comprises all nongenetic factors an individual is exposed to
across their lifespan. Research suggests that exposomic vulnerability for schizophrenia is …

Gene–environment (GxE) interactions have been related to psychosis spectrum disorders,
involving multiple common genetic variants in multiple genes with very small effect sizes …

BackgroundA cumulative environmental exposure score for schizophrenia (exposome score
for schizophrenia [ES-SCZ]) may provide potential utility for risk stratification and outcome …

AimsPsychosis spectrum disorder has a complex pathoetiology characterised by interacting
environmental and genetic vulnerabilities. The present study aims to investigate the role of …

Schizophrenia is a heritable complex phenotype associated with a background risk
involving multiple common genetic variants of small effect and a multitude of environmental …

Identifying modifiable factors through environmental research may improve mental health
outcomes. However, several challenges need to be addressed to optimize the chances of …