The evidence for associations between genetic polymorphisms and complex behavioral/
psychological phenotypes (traits) has thus far been weak and inconsistent. Using the well …

BACKGROUND: Cognitive endophenotypes may further our understanding of the genetic
basis of psychiatric disorders, and the catechol-O-methyltransferase (COMT) gene is a …

The Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene may be
related to individual differences in cognition, likely via modulation of prefrontal dopamine …

Across different personality theories, there is agreement that dopamine is the neurochemical
basis of extraversion. However, evidence from molecular genetics for the validity of this …

Genetic variation in catechol-O-methyltransferase (COMT), encoding an enzyme critical for
prefrontal dopamine flux, has been studied extensively using both behavioral and …

A polymorphism (Val158Met) in the gene for catechol-O-methyl transferase (COMT) was
previously associated with differences in cognitive ability and personality. Here we examine …

Efforts to identify genetic factors that confer an increased risk for the expression of
psychiatric symptoms have focused on polymorphisms in variety of candidate genes …

The important contribution of genetic factors to the development of cognition and intelligence
is widely acknowledged, but identification of these genes has proven to be difficult. Given a …

The enzyme catechol-O-methyl transferase (COMT), identified in the 1950s, is involved in
catabolism of monoamines that are influenced by psychotropic medications, including …

OBJECTIVE: It has been suggested that variation in catechol O-methyltransferase (COMT)
activity associated with variation in COMT Val158Met genotypes may result in enhanced or …