Brain metabolic changes in major depressive disorder from pre-to post-treatment with paroxetine

AL Brody, S Saxena, DHS Silverman… - Psychiatry Research …, 1999 - Elsevier
Functional brain imaging studies of subjects with Major Depressive Disorder (MDD) have
suggested that decreased dorsolateral (DLPFC) and increased ventrolateral (VLPFC) …

Regional brain metabolic changes in patients with major depression treated with either paroxetine or interpersonal therapy: preliminary findings

AL Brody, S Saxena, P Stoessel… - Archives of general …, 2001 - jamanetwork.com
Background In functional brain imaging studies of major depressive disorder (MDD),
regional abnormalities have been most commonly found in prefrontal cortex, anterior …

Brain metabolic changes associated with symptom factor improvement in major depressive disorder

AL Brody, S Saxena, MA Mandelkern, LA Fairbanks… - Biological …, 2001 - Elsevier
Background: Symptoms of major depressive disorder (MDD) have been linked to regional
brain function through imaging studies of symptom provocation in normal control subjects …

Metabolic changes within the left dorsolateral prefrontal cortex occurring with electroconvulsive therapy in patients with treatment resistant unipolar depression

N Michael, A Erfurth, P Ohrmann, V Arolt… - Psychological …, 2003 - cambridge.org
Background. The dorsolateral prefrontal cortex (DLPFC) is involved in the pathophysiology
of major depression. In particular, metabolic (functional hypometabolism) and structural …

Imbalance between left and right dorsolateral prefrontal cortex in major depression is linked to negative emotional judgment: an fMRI study in severe major depressive …

S Grimm, J Beck, D Schuepbach, D Hell, P Boesiger… - Biological …, 2008 - Elsevier
BACKGROUND: Although recent neuroimaging and therapeutic transcranial magnetic
cortex stimulation (TMS) studies suggest imbalance between left and right dorsolateral …

Modulation of cortical-limbic pathways in major depression: treatment-specific effects of cognitive behavior therapy

K Goldapple, Z Segal, C Garson, M Lau… - Archives of general …, 2004 - jamanetwork.com
Background Functional imaging studies of major depressive disorder demonstrate response-
specific regional changes following various modes of antidepressant treatment. Objective To …

Prefrontal-subcortical and limbic circuit mediation of major depressive disorder.

AL Brody, MW Barsom, RG Bota… - Seminars in clinical …, 2001 - europepmc.org
Substantial progress has been made in elucidating the pathophysiology of major depressive
disorder (MDD) using functional and structural brain imaging. In functional imaging studies …

Increased left prefrontal activation in patients with unipolar depression: an event-related, parametric, performance-controlled fMRI study

H Walter, RC Wolf, M Spitzer, N Vasic - Journal of affective disorders, 2007 - Elsevier
BACKGROUND: Executive deficits associated with frontal lobe dysfunction are prominent in
depression. We applied a newly developed WM task to investigate the neural correlates of …

Executive dysfunction predicts nonresponse to fluoxetine in major depression

JJ Dunkin, AF Leuchter, IA Cook… - Journal of affective …, 2000 - Elsevier
Background: Functional brain imaging studies of major depression have consistently
revealed hypometabolism or hypoperfusion in specific regions of the prefrontal cortex and …

Neural response to catecholamine depletion in unmedicated subjects with major depressive disorder in remission and healthy subjects

G Hasler, S Fromm, PJ Carlson… - Archives of general …, 2008 - jamanetwork.com
Context The pathophysiologic mechanism of major depressive disorder (MDD) has been
consistently associated with altered catecholaminergic function, especially with decreased …