Sepsis, a manifestation of the body's inflammatory response to injury and infection, has a
mortality rate of between 28%-50% and affects approximately 1 million patients annually in …

Sepsis is a life-threatening condition affecting one million people per year in the US in which
dysregulation of the body's own immune system causes damage to its tissues, resulting in a …

Abstract Systems biology is the comprehensive and quantitative analysis of the interactions
between all of the components of biological systems over time. Cells of the innate immune …

Introduction: Disease states are being characterized at finer and finer levels of resolution via
biomarker or gene expression profiles, while at the same time. Machine learning (ML) is …

Introduction: Accounting for biological heterogeneity represents one of the greatest
challenges in biomedical research. Dynamic computational and mathematical models can …

Objectives Sepsis affects nearly 1 million people in the United States per year, has a
mortality rate of 28–50% and requires more than $20 billion a year in hospital costs. Over a …

The understanding of the immune response is right now at the center of biomedical
research. There are growing expectations that immune-based interventions will in the …

Critical illness, a constellation of interrelated inflammatory and physiological derangements
occurring subsequent to severe infection or injury, affects a large number of individuals in …

A central goal of industrialized nations is to provide personalized, pre-emptive and
predictive medicine, while maintaining healthcare costs at a minimum. To do so, we must …

Immune responses to pathogens are complex and not well understood in many diseases,
and this is especially true for infections by persistent pathogens. One mechanism that allows …