[HTML][HTML] SARS-CoV-2 spike protein S1 activates Cx43 hemichannels and disturbs intracellular Ca2+ dynamics

J Prieto-Villalobos, CM Lucero, M Rovegno… - Biological Research, 2023 - Springer
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the
ongoing coronavirus disease 2019 (COVID-19). An aspect of high uncertainty is whether the …

[HTML][HTML] Effects of drugs formerly proposed for COVID-19 treatment on connexin43 hemichannels

A Cooreman, A Caufriez, A Tabernilla… - International Journal of …, 2022 - mdpi.com
Connexin43 (Cx43) hemichannels form a pathway for cellular communication between the
cell and its extracellular environment. Under pathological conditions, Cx43 hemichannels …

Human coronavirus OC43 infection remodels connexin 43-mediated gap junction intercellular communication in vitro

S Karmakar, J Das Sarma - Journal of Virology, 2024 - Am Soc Microbiol
ABSTRACT β-coronaviruses cause acute infection in the upper respiratory tract, resulting in
various symptoms and clinical manifestations. OC43 is a human β-coronavirus that induces …

[HTML][HTML] SARS-CoV-2 spike protein disrupts blood–brain barrier integrity via RhoA activation

BJ DeOre, KA Tran, AM Andrews, SH Ramirez… - Journal of Neuroimmune …, 2021 - Springer
The SARS-CoV-2 spike protein has been shown to disrupt blood–brain barrier (BBB)
function, but its pathogenic mechanism of action is unknown. Whether angiotensin …

Landscape of SARS-CoV-2 spike protein-interacting cells in human tissues

B Zheng, M Yuan, Q Ma, S Wang, Y Tan, Y Xu… - International …, 2021 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic. However, the …

SARS-CoV-2 Attachment to Host Cells is Possibly Mediated via RGD-Inte grin Interaction in a Calcium-dependent Manner

TC Dakal - 2020 - osf.io
Our study revealed that SARS-CoV-2 harbors a RGD motif in its receptor binding domain
(RBD) and the motif is absent in all previously known SARS-CoVs. The RGD motif plays a …

SARS‐CoV‐2 induces blood‐brain barrier and choroid plexus barrier impairments and vascular inflammation in mice

H Qiao, X Deng, L Qiu, Y Qu, Y Chiu… - Journal of medical …, 2024 - Wiley Online Library
The coronavirus disease of 2019 (COVID‐19) pandemic has led to more than 700 million
confirmed cases and nearly 7 million deaths. Although severe acute respiratory syndrome …

[HTML][HTML] Regulation of epithelial sodium channel activity by SARS-CoV-1 and SARS-CoV-2 proteins

SN Grant, HA Lester - Biophysical journal, 2021 - cell.com
Severe acute respiratory syndrome (SARS) coronavirus (CoV) 2 (SARS-CoV-2), which
causes the coronavirus disease 2019, encodes several proteins whose roles are poorly …

[PDF][PDF] Inflammation Induction in the Neurovascular Unit by the S1 Subunit of SARS-CoV-2 Strains

MM Stangis - 2023 - scholarship.miami.edu
Neurological symptoms and complications are prevalent in COVID-19 infection; therefore,
interactions of SARS-CoV-2 with cerebral microvascular cells became an emerging concern …

The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of …

E Avolio, M Carrabba, R Milligan… - Clinical …, 2021 - portlandpress.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a broad range
of clinical responses including prominent microvascular damage. The capacity of SARS …