Chromatin accessibility profiling by ATAC-seq

FC Grandi, H Modi, L Kampman, MR Corces - Nature protocols, 2022 - nature.com
The assay for transposase-accessible chromatin using sequencing (ATAC-seq) provides a
simple and scalable way to detect the unique chromatin landscape associated with a cell …

[HTML][HTML] From reads to insight: a hitchhiker's guide to ATAC-seq data analysis

F Yan, DR Powell, DJ Curtis, NC Wong - Genome biology, 2020 - Springer
Abstract Assay of Transposase Accessible Chromatin sequencing (ATAC-seq) is widely
used in studying chromatin biology, but a comprehensive review of the analysis tools has …

[HTML][HTML] Detect accessible chromatin using ATAC-sequencing, from principle to applications

Y Sun, N Miao, T Sun - Hereditas, 2019 - Springer
Background Chromatin accessibility is crucial for gene expression regulation in specific cells
and in multiple biological processes. Assay for Transposase Accessible Chromatin with high …

[HTML][HTML] Assessment of computational methods for the analysis of single-cell ATAC-seq data

H Chen, C Lareau, T Andreani, ME Vinyard, SP Garcia… - Genome biology, 2019 - Springer
Background Recent innovations in single-cell Assay for Transposase Accessible Chromatin
using sequencing (scATAC-seq) enable profiling of the epigenetic landscape of thousands …

[HTML][HTML] ATACseqQC: a Bioconductor package for post-alignment quality assessment of ATAC-seq data

J Ou, H Liu, J Yu, MA Kelliher, LH Castilla, ND Lawson… - BMC genomics, 2018 - Springer
Background ATAC-seq (Assays for Transposase-Accessible Chromatin using sequencing)
is a recently developed technique for genome-wide analysis of chromatin accessibility …

A plate-based single-cell ATAC-seq workflow for fast and robust profiling of chromatin accessibility

W Xu, Y Wen, Y Liang, Q Xu, X Wang, W Jin, X Chen - Nature protocols, 2021 - nature.com
Profiling chromatin accessibility at the single-cell level provides critical information about cell
type composition and cell-to-cell variation within a complex tissue. Emerging techniques for …

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

JD Buenrostro, PG Giresi, LC Zaba, HY Chang… - Nature …, 2013 - nature.com
We describe an assay for transposase-accessible chromatin using sequencing (ATAC-seq),
based on direct in vitro transposition of sequencing adaptors into native chromatin, as a …

[HTML][HTML] An ATAC-seq atlas of chromatin accessibility in mouse tissues

C Liu, M Wang, X Wei, L Wu, J Xu, X Dai, J Xia… - Scientific data, 2019 - nature.com
Abstract The Assay for Transposase-Accessible Chromatin using sequencing (ATAC-seq) is
a fundamental epigenomics approach and has been widely used in profiling the chromatin …

Scalable, multimodal profiling of chromatin accessibility, gene expression and protein levels in single cells

EP Mimitou, CA Lareau, KY Chen… - Nature …, 2021 - nature.com
Recent technological advances have enabled massively parallel chromatin profiling with
scATAC-seq (single-cell assay for transposase accessible chromatin by sequencing). Here …

[PDF][PDF] PEPATAC: an optimized pipeline for ATAC-seq data analysis with serial alignments

JP Smith, MR Corces, J Xu, VP Reuter… - NAR genomics and …, 2021 - academic.oup.com
As chromatin accessibility data from ATAC-seq experiments continues to expand, there is
continuing need for standardized analysis pipelines. Here, we present PEPATAC, an ATAC …