Glial cells in schizophrenia: a unified hypothesis

AG Dietz, SA Goldman, M Nedergaard - The Lancet Psychiatry, 2020 - thelancet.com
The cellular neurobiology of schizophrenia remains poorly understood. We discuss
neuroimaging studies, pathological findings, and experimental work supporting the idea that …

Glial cells as key players in schizophrenia pathology: recent insights and concepts of therapy

HG Bernstein, J Steiner, PC Guest, H Dobrowolny… - Schizophrenia …, 2015 - Elsevier
The past decade has witnessed an explosion of knowledge on the impact of glia for the
neurobiological foundation of schizophrenia. A plethora of studies have shown structural …

Glial cells in schizophrenia: pathophysiological significance and possible consequences for therapy

HG Bernstein, J Steiner, B Bogerts - Expert review of …, 2009 - Taylor & Francis
In the last 10 years, structural, molecular and functional changes in glial cells have become
a major focus of interest in the search for the neurobiological foundations of schizophrenia …

Astrocytes in schizophrenia

T Notter - Brain and Neuroscience Advances, 2021 - journals.sagepub.com
Schizophrenia is a severe and clinically heterogenous mental disorder affecting
approximately 1% of the population worldwide. Despite tremendous achievements in the …

Oligodendrocytes as a new therapeutic target in schizophrenia: from histopathological findings to neuron-oligodendrocyte interaction

FJ Raabe, L Slapakova, MJ Rossner… - Cells, 2019 - mdpi.com
Imaging and postmortem studies have revealed disturbed oligodendroglia-related
processes in patients with schizophrenia and provided much evidence for disturbed …

Oligodendrocyte dysfunction in schizophrenia and bipolar disorder

D Tkachev, ML Mimmack, MM Ryan, M Wayland… - The Lancet, 2003 - thelancet.com
Background Results of array studies have suggested abnormalities in expression of lipid
and myelin-related genes in schizophrenia. Here, we investigated oligodendrocyte-specific …

Schizophrenia.

MJ Owen, A Sawa, PB Mortensen - Lancet (London, England), 2016 - europepmc.org
Schizophrenia is a complex, heterogeneous behavioural and cognitive syndrome whose
origins appear to lie in genetic and/or environmental disruption of brain development …

Molecular and cellular evidence for an oligodendrocyte abnormality in schizophrenia

PR Hof, V Haroutunian, C Copland, KL Davis… - Neurochemical …, 2002 - Springer
Our previous analyses in postmortem prefrontal cortex samples from a well-characterized
cohort of severely affected schizophrenics and in matched controls demonstrated decreased …

Astrocyte decrease in the subgenual cingulate and callosal genu in schizophrenia

MR Williams, T Hampton, RKB Pearce… - European archives of …, 2013 - Springer
Decreases in glial cell density and in GFAP mRNA in the anterior cingulate cortex have
been reported in schizophrenia, bipolar disorder and major depressive disorder. Our study …

When cortical development goes wrong: schizophrenia as a neurodevelopmental disease of microcircuits

L Garey - Journal of anatomy, 2010 - Wiley Online Library
Schizophrenia probably has a developmental origin. This review refers to three of our
published series of studies related to this hypothesis: loss of dendritic spines on cerebral …