The immune system has evolued to recognize and respond to foreign substances that are
often associated with pathogenic agents. This response, if successful, leads to the …

The biochemical and molecular basis of higher organisms' responses to mechanical or
chemical insult have been conserved evolutionarily. The adaptable vertebrate immune …

A. THE IMMUNE RESPONSE The immune system is composed of a complex, interdigitated
network of cells and soluble factors. The function of the immune system is primarily to …

Publisher Summary This chapter discusses a broad array of lymphokines and monokines
that have marked biological effects on a variety of cell types, including B and T lymphocytes …

The immune system, like most complex systems, functions according to strict regulatory
mechanisms. The potential range of immune responses toward antigen challenge is …

The proliferation and differentiation of hematopoietic cells of both lymphoid and myeloid
lineages are governed by various polypeptide growth factors known as lymphokines …

The study oflymphokines (perhaps" cytokines" is a better generic term) is an area in which
data accumulate so quickly that it is virtually impossible for a book to be current even at the …

When a foreign material or infectious agent, termed antigen (s), penetrates natural defense
barriers and gains entry into the tissues of a mammalian host, specialized cells in the …

The lymphocyte—derived mediators known as lymphokines play important roles both as
regulators of the immune response and as the effector agents by which that response …

Publisher Summary This chapter provides an overview of soluble immune regulatory
molecules. An immune response to an invading pathogen is an essential mechanism to …