Soluble oligomers of amyloid-forming proteins are implicated as toxic species in the context
of several neurodegenerative diseases. Since the size and shape of these oligomers …

Oligomers comprised of misfolded proteins are implicated as neurotoxins in the
pathogenesis of protein misfolding conditions such as Parkinson's and Alzheimer's …

A30P and E46K are two mutants of α-synuclein (α-Syn) associated with familial early-onset
Parkinson's disease (PD), and amyloid fibrils of α-Syn are the hallmarks of this disease …

Abstract α-Synuclein is a protein that aggregates as amyloid fibrils in the brains of patients
with Parkinson's disease and dementia with Lewy bodies. Small oligomers of α-synuclein …

Proteinaceous deposits of α-synuclein amyloid fibrils are a hallmark of human disorders
including Parkinson's disease. The onset of this disease is also associated with five familial …

The quantification of α-synuclein aggregates has emerged as a promising biomarker for
synucleinopathies. Assays that amplify and detect such aggregates have revealed the …

Abstract α-Synuclein (α-Syn) is an abundant cytosolic protein involved in the release of
neurotransmitters in presynaptic terminal and its aberrant aggregation is found to be …

α-Synuclein (α-Syn) is an intrinsically disordered protein whose aggregation in the brain has
been significantly implicated in Parkinson's disease (PD). Beyond the brain, oligomers of α …

Understanding the mechanisms behind amyloid protein aggregation in diseases, such as
Parkinson's and Alzheimer's disease, is often hampered by the reproducibility of in vitro …

Small oligomers of the protein α-synuclein (αS) are highly cytotoxic species associated with
Parkinson's disease (PD). In addition, αS can form co-aggregates with its mutational variants …