Background: Erythrocytes (red blood cells) participate in the control of vascular NO
bioavailability. The purpose of this study was to determine whether and how genetic deletion …

The endothelial production of nitric oxide (NO) mediates endothelium-dependent
vasorelaxation and restrains vascular inflammation, smooth muscle cell proliferation, and …

Oxidized low-density lipoprotein (OxLDL) impairs NO signaling and endothelial function,
and contributes to the pathogenesis of atherosclerosis. Arginase reciprocally regulates NO …

Abstract Background and aims Arginase1 (Arg1), an M2 macrophage marker, plays a critical
role in a number of immunological functions in macrophages, which are the main cell type …

Decreased endothelial nitric oxide (NO) bioavailability as it relates to endothelial dysfunction
plays an important role in various cardiovascular disorders, including atherosclerosis …

Arginase, expressed in endothelial cells and upregulated in aging blood vessels, competes
with NO synthase (NOS) for l-arginine, thus modulating vasoreactivity and attenuating NO …

Objective.–Arginase is a nitric oxide synthase-alternative pathway for l-arginine breakdown
leading to biosynthesis of urea and l-ornithine. Arginase pathway is inducible by …

Oxidized low-density lipoproteins increase arginase activity and reciprocally decrease
endothelial NO in human aortic endothelial cells. Here, we demonstrate that vascular …

Background Cardiovascular disorders associated with endothelial dysfunction, such as
atherosclerosis, have decreased nitric oxide (NO) bioavailability. Arginase in the vasculature …

Endothelial function is impaired in aging because of a decrease in NO bioavailability. This
may be, in part, attributable to increased arginase activity, which reciprocally regulates NO …