Highlights•Current understanding of human nephron morphogenetic programs is
limited.•Tissue mechanics and cell fate specification may act in concert to shape the …

The ability to generate 3-dimensional models of the developing human kidney via the
directed differentiation of pluripotent stem cells—termed kidney organoids—has been hailed …

Kidney organoids derived from human induced pluripotent stem cells bear the potential to
be used as a regenerative medicine renal replacement therapy. Advances in developmental …

Kidney organoids made from pluripotent stem cells have the potential to revolutionize how
kidney development, disease, and injury are studied. Current protocols are technically …

There are now many reports of human kidney organoids generated via the directed
differentiation of human pluripotent stem cells (PSCs) based on an existing understanding of …

New research, published in Nature, describes the generation of kidney organoids from
human pluripotent stem cells (hPSCs). These organoids contained multiple nephron …

Kidney organoids differentiated from human pluripotent stem cells (hPSC) have advanced
the study of kidney diseases by providing an in vitro system that outperforms traditional …

We have previously reported a protocol for the directed differentiation of human induced
pluripotent stem cells to kidney organoids comprised of nephrons, proximal and distal …

Kidney organoids represent a physiologically advanced model for studying the mechanisms
of kidney development and disease. Here, we describe a simple two-step protocol for the …

The treatment of renal failure has seen little change in the past 70 years. Patients with end-
stage renal disease (ESRD) are treated with renal replacement therapy, including dialysis or …