Multiscale Molecular Dynamics Simulations of the Homodimer Accessory Protein ORF7b of SARS-CoV-2

MK Hsieh, JB Klauda - The Journal of Physical Chemistry B, 2023 - ACS Publications
The SARS-CoV-2 ORF7b protein has drawn attention for its potential role in viral
pathogenesis, but its structural details and lateral membrane associations remain elusive. In …

Structural and functional effects of the L84S mutant in the SARS-COV-2 ORF8 dimer based on microsecond molecular dynamics study

S Islam, MR Parves, MJ Islam, MA Ali… - Journal of …, 2024 - Taylor & Francis
The L84S mutation has been observed frequently in the ORF8 protein of SARS-CoV-2,
which is an accessory protein involved in various important functions such as virus …

Unraveling the impact of ORF3a Q57H mutation on SARS-CoV-2: insights from molecular dynamics

MJ Islam, MS Alom, MS Hossain, MA Ali… - Journal of …, 2023 - Taylor & Francis
ORF3a is a conserved accessory protein of SARS-CoV-2, linked to viral infection and
pathogenesis, with acquired mutations at various locations. Previous studies have shown …

In silico study on the effects of disulfide bonds in ORF8 of SARS-CoV-2

Y Cheng, X Peng - Physical Chemistry Chemical Physics, 2022 - pubs.rsc.org
The COVID-19 epidemic, caused by virus SARS-CoV-2, has turned into a pandemic and
threatened everyone's health for the past two years. In SARS-CoV-2, ORF8 is one of the …

Oligomer formation of SARS-CoV-2 ORF8 through 73YIDI76 motifs regulates immune response and non-infusion antiviral interactions

M Assadizadeh, M Azimzadeh Irani - Frontiers in Molecular …, 2023 - frontiersin.org
Introduction: Open Reading Frame 8 (ORF8) is a 121 amino acid length SARS-CoV-2
specific accessory protein that plays crucial roles in viral infectivity, and pathogenesis …

SARS-CoV-2 ORF8 dimerization and binding mode analysis with class I MHC: computational approaches to identify COVID-19 inhibitors

C Selvaraj, DC Dinesh, EM Pedone… - Briefings in …, 2023 - academic.oup.com
SARS-CoV-2 encodes eight accessory proteins, one of which, ORF8, has a poorly
conserved sequence with SARS-CoV and its role in viral pathogenicity has recently been …

Structural characterization of SARS-CoV-2 dimeric ORF9b reveals potential fold-switching trigger mechanism

X Jin, X Sun, Y Chai, Y Bai, Y Li, T Hao, J Qi… - Science China Life …, 2023 - Springer
The constant emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants indicates the evolution and adaptation of the virus. Enhanced innate immune …

Probing the mechanical properties of ORF3a protein, a transmembrane channel of SARS-CoV-2 virus: Molecular dynamics study

VM Maymand, O Bavi, A Karami - Chemical Physics, 2023 - Elsevier
Abstract SARS-CoV-2-encoded accessory protein ORF3a was found to be a conserved
coronavirus protein that shows crucial roles in apoptosis in cells as well as in virus release …

[HTML][HTML] Structure of SARS-CoV-2 ORF8, a rapidly evolving coronavirus protein implicated in immune evasion

TG Flower, CZ Buffalo, RM Hooy, M Allaire, X Ren… - Biorxiv, 2020 - ncbi.nlm.nih.gov
The molecular basis for the severity and rapid spread of the COVID-19 disease caused by
SARS-CoV-2 is largely unknown. ORF8 is a rapidly evolving accessory protein that has …

Structure of SARS-CoV-2 ORF8, a rapidly evolving immune evasion protein

TG Flower, CZ Buffalo, RM Hooy… - Proceedings of the …, 2021 - National Acad Sciences
The molecular basis for the severity and rapid spread of the COVID-19 disease caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is largely unknown. ORF8 …