A comprehensive gene-centric pleiotropic association analysis for 14 psychiatric disorders with GWAS summary statistics
H Lu, J Qiao, Z Shao, T Wang, S Huang, P Zeng - BMC medicine, 2021 - Springer
Background Recent genome-wide association studies (GWASs) have revealed the
polygenic nature of psychiatric disorders and discovered a few of single-nucleotide …
polygenic nature of psychiatric disorders and discovered a few of single-nucleotide …
Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate
Several lines of evidence suggest that genome-wide association studies (GWAS) have the
potential to explain more of the “missing heritability” of common complex phenotypes …
potential to explain more of the “missing heritability” of common complex phenotypes …
Examining the shared etiology of psychopathology with genome-wide association studies
TT Mallard, AD Grotzinger… - Physiological …, 2023 - journals.physiology.org
Genome-wide association studies (GWASs) have ushered in a new era of reproducible
discovery in psychiatric genetics. The field has now identified hundreds of common genetic …
discovery in psychiatric genetics. The field has now identified hundreds of common genetic …
Dimensional and transdiagnostic phenotypes in psychiatric genome-wide association studies
Genome-wide association studies (GWAS) provide biological insights into disease onset
and progression and have potential to produce clinically useful biomarkers. A growing body …
and progression and have potential to produce clinically useful biomarkers. A growing body …
Conditional GWAS analysis to identify disorder-specific SNPs for psychiatric disorders
Substantial genetic liability is shared across psychiatric disorders but less is known about
risk variants that are specific to a given disorder. We used multi-trait conditional and joint …
risk variants that are specific to a given disorder. We used multi-trait conditional and joint …
Multi-trait analysis for genome-wide association study of five psychiatric disorders
We conducted a cross-trait meta-analysis of genome-wide association study on
schizophrenia (SCZ)(n= 65,967), bipolar disorder (BD)(n= 41,653), autism spectrum …
schizophrenia (SCZ)(n= 65,967), bipolar disorder (BD)(n= 41,653), autism spectrum …
Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation
Accumulating evidence from genome wide association studies (GWAS) suggests an
abundance of shared genetic influences among complex human traits and disorders, such …
abundance of shared genetic influences among complex human traits and disorders, such …
Pervasive pleiotropy between psychiatric disorders and immune disorders revealed by integrative analysis of multiple GWAS
Although some existing epidemiological observations and molecular experiments
suggested that brain disorders in the realm of psychiatry may be influenced by immune …
suggested that brain disorders in the realm of psychiatry may be influenced by immune …
The emerging pattern of shared polygenic architecture of psychiatric disorders, conceptual and methodological challenges
Genome-wide association studies have transformed psychiatric genetics and provided novel
insights into the genetic etiology of psychiatric disorders. Two major discoveries have …
insights into the genetic etiology of psychiatric disorders. Two major discoveries have …
Exploring the genetic overlap between twelve psychiatric disorders
The widespread comorbidity among psychiatric disorders demonstrated in epidemiological
studies,,,–is mirrored by non-zero, positive genetic correlations from large-scale genetic …
studies,,,–is mirrored by non-zero, positive genetic correlations from large-scale genetic …