[HTML][HTML] Efficacy and blood plasmalogen changes by oral administration of plasmalogen in patients with mild Alzheimer's disease and mild cognitive impairment: a …

T Fujino, T Yamada, T Asada, Y Tsuboi, C Wakana… - …, 2017 - thelancet.com
Abstract Background Plasmalogens (Pls) reportedly decreased in postmortem brain and in
the blood of patients with Alzheimer's disease (AD). Recently we showed that intraperitoneal …

Oral ingestion of plasmalogens can attenuate the LPS-induced memory loss and microglial activation

MS Hossain, A Tajima, S Kotoura, T Katafuchi - … and biophysical research …, 2018 - Elsevier
Plasmalogens (Pls) are the special phospholipids which were reported to be reduced in
brain and blood samples of Alzheimer's disease (AD) patients, suggested a possibility that …

Circulating plasmalogen levels and Alzheimer disease assessment scale–cognitive scores in Alzheimer patients

PL Wood, R Mankidy, S Ritchie, D Heath… - Journal of Psychiatry and …, 2010 - jpn.ca
Background: Plasmalogens, which are key structural phospholipids in brain membranes, are
decreased in the brain and serum of patients with Alzheimer disease (AD). We performed …

[HTML][HTML] Plasmalogens eliminate aging-associated synaptic defects and microglia-mediated neuroinflammation in mice

J Gu, L Chen, R Sun, JL Wang, J Wang… - Frontiers in Molecular …, 2022 - frontiersin.org
Neurodegeneration is a pathological condition in which nervous system or neuron losses its
structure, function, or both leading to progressive neural degeneration. Growing evidence …

Biological functions of plasmalogens

MS Hossain, S Mawatari, T Fujino - Peroxisome biology: Experimental …, 2020 - Springer
Plasmalogens (Pls) are one kind of phospholipids enriched in the brain and other organs.
These lipids were thought to be involved in the membrane bilayer formation and anti-oxidant …

[HTML][HTML] Plasmalogens and Alzheimer's disease: a review

XQ Su, J Wang, AJ Sinclair - Lipids in health and disease, 2019 - Springer
Growing evidence suggests that ethanolamine plasmalogens (PlsEtns), a subtype of
phospholipids, have a close association with Alzheimer's disease (AD). Decreased levels of …

Plasmalogen deficiency in early Alzheimer's disease subjects and in animal models: molecular characterization using electrospray ionization mass spectrometry

X Han, DM Holtzman… - Journal of …, 2001 - Wiley Online Library
To explore the hypothesis that alterations in ethanolamine plasmalogen may be directly
related to the severity of dementia in Alzheimer's disease (AD), we performed a systematic …

[HTML][HTML] Targeted plasmalogen supplementation: Effects on blood plasmalogens, oxidative stress biomarkers, cognition, and mobility in cognitively impaired persons

DB Goodenowe, J Haroon, MA Kling… - Frontiers in cell and …, 2022 - frontiersin.org
Plasmalogens are a specific type of glycerophospholipid found in especially high levels in
neuronal membranes. Decreased blood and brain levels of docosahexaenoic acid (DHA) …

[HTML][HTML] Plasmalogens inhibit neuroinflammation and promote cognitive function

MS Hossain, S Mawatari, T Fujino - Brain Research Bulletin, 2023 - Elsevier
Neuroinflammation (NF) is defined as the activation of brain glial cells that are found in
neurodegenerative diseases including Alzheimer's disease (AD). It has been known that an …

Accurate quantitation of choline and ethanolamine plasmalogen molecular species in human plasma by liquid chromatography–tandem mass spectrometry

Y Otoki, S Kato, F Kimura, K Furukawa… - … of Pharmaceutical and …, 2017 - Elsevier
Concentration of both choline plasmalogen (PC-Pls) and ethanolamine Pls (PE-Pls) in
human plasma/serum has been getting attention to, since certain patients including those …