Different lesions have been suggested to represent preneoplastic conditions in human liver.
They include liver cell dysplasia, separated in large-cell change (LCC) and small-cell …

Foci of altered hepatocytes (FAH) represent preneoplastic lesions, as shown in various
animal models of hepatocarcinogenesis, but their significance in the human liver has not …

Among the different types of liver tumor, hepatocellular neoplasms predominate by far in
both animals and man. Consequently, preneoplastic foci of altered hepatocytes (FAH) …

Hepatic preneoplasia represents an early stage in neoplastic development, preceding both
benign and malignant neoplasia. This applies particularly to foci of altered hepatocytes …

In this comparative review, histomorphological features of common nonneoplastic and
neoplastic hepatocyte lesions of rats and humans are examined using H&E-stained slides …

The early stages of hepatocarcinogenesis in human chronic liver diseases are characterized
by the emergence of preneoplastic lesions of which some will eventually develop into …

Preneoplastic and neoplastic hepatic lesions were induced in male Sprague–Dawley rats by
oral exposure to N-nltrosomorpholine (12 mg/kg body wt/day) for 7 weeks (stop model) …

In the early stage of chemically induced hepatocarcinogenesis, rare hepatocytes are
transformed into preneoplastic hepatocytes, which progressively evolve into cells with …

Large cell change (LCC), characterized by cellular enlargement, nuclear pleomorphism and
hyperchromasia, and multinucleation of hepatocytes, is a common lesion in cirrhotic livers …

In recent years, a growing literature has supported the concept that large nodules usually
found in cirrhotic livers represent premalignant lesions in the setting of chronic liver disease …