Background Recent evidence suggests that B cells and autoantibodies have a substantial
role in the pathogenesis of Multiple sclerosis. T cells could be engineered to express …

The role of autoreactive, antigen-specific T-cells in the development of autoimmunity has
long been documented. T-cells expressing chimeric receptors are specifically redirected …

While over the past decades T cells have been considered key players in the pathogenesis
of multiple sclerosis (MS), it has only recently become evident that B cells have a major …

Autoimmune diseases are caused by breaking the central and/or peripheral tolerance
against self, leading to uncontrolled immune response to autoantigens. The incidences of …

Despite significant breakthroughs in understanding of immunological and physiological
features of autoimmune diseases, there is currently no specific therapeutic option with …

Whether B cells serve as antigen-presenting cells (APCs) for activation of pathogenic T cells
in the multiple sclerosis model experimental autoimmune encephalomyelitis (EAE) is …

Autoimmune disorders occur when immune cells go wrong and attack the body's own
tissues. Currently, autoimmune disorders are largely treated by broad immunosuppressive …

The therapeutic success and widespread approval of genetically engineered T cells for a
variety of hematologic malignancies spurred the development of synthetic cell-based …

Previous work by our group showed that transferring bone marrow cells transduced with a
self-antigen induced immune tolerance and ameliorated experimental autoimmune …

Background and Objectives Anti-CD20 monoclonal antibody (mAb) B-cell depletion is a
remarkably successful multiple sclerosis (MS) treatment. Chimeric antigen receptor (CAR)-T …