Class I HLA haplotypes form two schools that educate NK cells in different ways
A Horowitz, Z Djaoud, N Nemat-Gorgani… - Science …, 2016 - science.org
Natural killer (NK) cells are lymphocytes that have vital functions in innate and adaptive
immunity, as well as placental reproduction. Polymorphic human leukocyte antigen (HLA) …
immunity, as well as placental reproduction. Polymorphic human leukocyte antigen (HLA) …
Missing or altered self: human NK cell receptors that recognize HLA-C
HG Hilton, P Parham - Immunogenetics, 2017 - Springer
Natural killer (NK) cells are fast-acting and versatile lymphocytes that are critical effectors of
innate immunity, adaptive immunity, and placental development. Controlling NK cell function …
innate immunity, adaptive immunity, and placental development. Controlling NK cell function …
Co-evolution of KIR2DL3 with HLA-C in a human population retaining minimal essential diversity of KIR and HLA class I ligands
K Gendzekhadze, PJ Norman… - Proceedings of the …, 2009 - National Acad Sciences
Natural killer (NK) cells contribute to immunity and reproduction. Guiding these functions,
and NK cell education, are killer cell Ig-like receptors (KIR), NK cell receptors that recognize …
and NK cell education, are killer cell Ig-like receptors (KIR), NK cell receptors that recognize …
Mutation at positively selected positions in the binding site for HLA-C shows that KIR2DL1 is a more refined but less adaptable NK cell receptor than KIR2DL3
Through recognition of HLA class I, killer cell Ig-like receptors (KIR) modulate NK cell
functions in human immunity and reproduction. Although a minority of HLA-A and-B …
functions in human immunity and reproduction. Although a minority of HLA-A and-B …
[HTML][HTML] Diverse functionality among human NK cell receptors for the C1 epitope of HLA-C: KIR2DS2, KIR2DL2, and KIR2DL3
AK Moesta, P Parham - Frontiers in immunology, 2012 - frontiersin.org
Interactions between killer immunoglobulin-like receptors (KIRs) and their HLA-A,-B, and-C
ligands diversify the functions of human natural killer cells. Consequently, combinations of …
ligands diversify the functions of human natural killer cells. Consequently, combinations of …
Genetics of natural killer cells in human health, disease, and survival
P Parham, LA Guethlein - Annual Review of Immunology, 2018 - annualreviews.org
Natural killer (NK) cells have vital functions in human immunity and reproduction. In the
innate and adaptive immune responses to infection, particularly by viruses, NK cells respond …
innate and adaptive immune responses to infection, particularly by viruses, NK cells respond …
Human-specific evolution of killer cell immunoglobulin-like receptor recognition of major histocompatibility complex class I molecules
P Parham, PJ Norman… - … Transactions of the …, 2012 - royalsocietypublishing.org
In placental mammals, natural killer (NK) cells are a population of lymphocytes that make
unique contributions to immune defence and reproduction, functions essential for survival of …
unique contributions to immune defence and reproduction, functions essential for survival of …
Coevolution of killer cell Ig-like receptors with HLA-C to become the major variable regulators of human NK cells
AM Older Aguilar, LA Guethlein, EJ Adams… - The Journal of …, 2010 - journals.aai.org
Interactions between HLA class I and killer cell Ig-like receptors (KIRs) diversify human NK
cell responses. Dominant KIR ligands are the C1 and C2 epitopes of MHC-C, a young locus …
cell responses. Dominant KIR ligands are the C1 and C2 epitopes of MHC-C, a young locus …
Innate receptors with high specificity for HLA class I–peptide complexes
Genetic studies associate killer cell immunoglobulin-like receptors (KIRs) and their HLA
class I ligands with a variety of human diseases. The basis for these associations and the …
class I ligands with a variety of human diseases. The basis for these associations and the …
HLA class I signal peptide polymorphism determines the level of CD94/NKG2–HLA-E-mediated regulation of effector cell responses
Z Lin, AA Bashirova, M Viard, L Garner, M Quastel… - Nature …, 2023 - nature.com
Human leukocyte antigen (HLA)-E binds epitopes derived from HLA-A, HLA-B, HLA-C and
HLA-G signal peptides (SPs) and serves as a ligand for CD94/NKG2A and CD94/NKG2C …
HLA-G signal peptides (SPs) and serves as a ligand for CD94/NKG2A and CD94/NKG2C …