The state of chromatin (the packaging of DNA in eukaryotes) has long been recognized to
have major effects on levels of gene expression, and numerous chromatin-altering …

The role of histone acetylation as a key mechanism of transcriptional regulation has been
well established. Recent advances suggest that histone acetyltransferases also play …

Eukaryotic DNA is packaged into chromatin by histone proteins, which assemble the DNA
into an organized, higher-order structure. The precise organization of chromatin is essential …

Transcriptionally active DNA is packaged with histones that are post-translationally
acetylated on multiple lysines within their amino termini. While the majority of this acetylation …

In eukaryotes, DNA is assembled with histones to form nucleosomes, the basic subunit of
chromatin structure. The wrapping of DNA around histone octamers to form nucleosomal …

All four histones of the nucleosome core particle are subject to post-translational acetylation
of selected lysine residues in their amino-terminal domains. The modification is ubiquitous …

Post-translational modification of histones, a major protein component of eukaryotic
chromosomes, contributes to the epigenetic regulation of gene expression. Distinct patterns …

Acetylation of internal lysine residues of core histone N‐terminal domains has been found
correlatively associated with transcriptional activation in eukaryotes for more than three …

Several transcriptional regulators have been found to act as enzymes that acetylate
histones. The targeted post-translational modification of histones within regulatory …

More than 30 years ago, Vincent Allfrey proposed that histone acetylation was associated
with transcriptional activity in eukaryotic cells (Allfrey et al. 1964; Pogo et al. 1966) …