MemPrep, a new technology for isolating organellar membranes provides fingerprints of lipid bilayer stress
Biological membranes have a stunning ability to adapt their composition in response to
physiological stress and metabolic challenges. Little is known how such perturbations affect …
physiological stress and metabolic challenges. Little is known how such perturbations affect …
A new technology for isolating organellar membranes provides fingerprints of lipid bilayer stress
Biological membranes have a stunning ability to adapt their composition in response to
physiological stress and metabolic challenges. Little is known how such perturbations affect …
physiological stress and metabolic challenges. Little is known how such perturbations affect …
A quantitative analysis of cellular lipid compositions during acute proteotoxic ER stress reveals specificity in the production of asymmetric lipids
J Reinhard, C Mattes, K Väth, T Radanović… - Frontiers in Cell and …, 2020 - frontiersin.org
The unfolded protein response (UPR) is central to endoplasmic reticulum (ER) homeostasis
by controlling its size and protein folding capacity. When activated by unfolded proteins in …
by controlling its size and protein folding capacity. When activated by unfolded proteins in …
Membrane phospholipid alteration causes chronic ER stress through early degradation of homeostatic ER-resident proteins
P Shyu Jr, BSH Ng, N Ho, R Chaw, YL Seah… - Scientific reports, 2019 - nature.com
Phospholipid homeostasis in biological membranes is essential to maintain functions of
organelles such as the endoplasmic reticulum. Phospholipid perturbation has been …
organelles such as the endoplasmic reticulum. Phospholipid perturbation has been …
Endoplasmic reticulum membrane homeostasis and the unfolded protein response
The endoplasmic reticulum (ER) is the key organelle for membrane biogenesis. Most lipids
are synthesized in the ER, and most membrane proteins are first inserted into the ER …
are synthesized in the ER, and most membrane proteins are first inserted into the ER …
Integrated functions of membrane property sensors and a hidden side of the unfolded protein response
Eukaryotic cells face the challenge of maintaining the complex composition of several
coexisting organelles. The molecular mechanisms underlying the homeostasis of …
coexisting organelles. The molecular mechanisms underlying the homeostasis of …
Regulation of lipid metabolism: a tale of two yeasts
S Raychaudhuri, BP Young, PJ Espenshade… - Current opinion in cell …, 2012 - Elsevier
Eukaryotic cells synthesize multiple classes of lipids by distinct metabolic pathways in order
to generate membranes with optimal physical and chemical properties. As a result, complex …
to generate membranes with optimal physical and chemical properties. As a result, complex …
Stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress
Membrane integrity at the endoplasmic reticulum (ER) is tightly regulated, and its
disturbance is implicated in metabolic diseases. Using an engineered sensor that activates …
disturbance is implicated in metabolic diseases. Using an engineered sensor that activates …
Beyond proteostasis: lipid metabolism as a new player in ER homeostasis
J Xu, S Taubert - Metabolites, 2021 - mdpi.com
Biological membranes are not only essential barriers that separate cellular and subcellular
structures, but also perform other critical functions such as the initiation and propagation of …
structures, but also perform other critical functions such as the initiation and propagation of …
Membrane homeostasis beyond fluidity: control of membrane compressibility
Biomembranes are complex materials composed of lipids and proteins that
compartmentalize biochemistry. They are actively remodeled in response to physical and …
compartmentalize biochemistry. They are actively remodeled in response to physical and …