Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the virus that causes
COVID-19, continues to evolve resistance to vaccines and existing antiviral therapies at an …

Understanding the core replication complex of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) is essential to the development of novel coronavirus-specific …

The risk of zoonotic coronavirus spillover into the human population, as highlighted by the
SARS-CoV-2 pandemic, demands the development of pan-coronavirus antivirals. The …

SARS-CoV-2 has an exonuclease-based proofreader, which removes nucleotide inhibitors
such as Remdesivir that are incorporated into the viral RNA during replication, reducing the …

High-fidelity replication of the large RNA genome of coronaviruses (CoVs) is mediated by a
3′-to-5′ exoribonuclease (ExoN) in nonstructural protein 14 (nsp14), which excises …

The rapid global emergence of SARS-CoV-2 has been the cause of significant health
concern, highlighting the immediate need for antivirals. Viral RNA-dependent RNA …

Coronaviruses (CoVs) stand out for their large RNA genome and complex RNA-synthesizing
machinery comprising 16 nonstructural proteins (nsps). The bifunctional nsp14 contains 3 …

With the recent global spread of new SARS-CoV-2 variants, there remains an urgent need to
develop effective and variant-resistant oral drugs. Recently, we reported in vitro results …

With the recent global spread of new SARS-CoV-2 variants, there remains an urgent need to
develop effective and variant-resistant oral drugs. Recently, we reported in vitro results …

The on-going global pandemic of COVID-19 is caused by SARS-CoV-2, which features a
proofreading mechanism to facilitate the replication of its large RNA genome. The 3′-to-5 …