Contribution of relapse-independent progression vs relapse-associated worsening to overall confirmed disability accumulation in typical relapsing multiple sclerosis in …
Importance Accumulation of disability in multiple sclerosis may occur as relapse-associated
worsening (RAW) or steady progression independent of relapse activity (PIRA), with PIRA …
worsening (RAW) or steady progression independent of relapse activity (PIRA), with PIRA …
Silent progression in disease activity–free relapsing multiple sclerosis
University of California, San Francisco MS … - Annals of …, 2019 - Wiley Online Library
Objective Rates of worsening and evolution to secondary progressive multiple sclerosis
(MS) may be substantially lower in actively treated patients compared to natural history …
(MS) may be substantially lower in actively treated patients compared to natural history …
Association of brain atrophy with disease progression independent of relapse activity in patients with relapsing multiple sclerosis
A Cagol, S Schaedelin, M Barakovic, P Benkert… - JAMA …, 2022 - jamanetwork.com
Importance The mechanisms driving neurodegeneration and brain atrophy in relapsing
multiple sclerosis (RMS) are not completely understood. Objective To determine whether …
multiple sclerosis (RMS) are not completely understood. Objective To determine whether …
Greater sensitivity to multiple sclerosis disability worsening and progression events using a roving versus a fixed reference value in a prospective cohort study
Background: Confirmed Expanded Disability Status Scale (EDSS) progression occurring
after a fixed-study entry baseline is a common measure of disability increase in relapsing …
after a fixed-study entry baseline is a common measure of disability increase in relapsing …
Comparative efficacy of disease-modifying therapies for patients with relapsing remitting multiple sclerosis: systematic review and network meta-analysis
Introduction Randomised studies have demonstrated efficacy of disease-modifying
therapies in relapsing remitting multiple sclerosis (RRMS). However it is unclear how the …
therapies in relapsing remitting multiple sclerosis (RRMS). However it is unclear how the …
[HTML][HTML] Ocrelizumab efficacy in subgroups of patients with relapsing multiple sclerosis
Objective The efficacy and safety of ocrelizumab, versus interferon (IFN) β-1a, for the
treatment of relapsing multiple sclerosis (RMS) from the identically designed OPERA I …
treatment of relapsing multiple sclerosis (RMS) from the identically designed OPERA I …
Association of early progression independent of relapse activity with long-term disability after a first demyelinating event in multiple sclerosis
C Tur, P Carbonell-Mirabent, Á Cobo-Calvo… - JAMA …, 2023 - jamanetwork.com
Importance Progression independent of relapse activity (PIRA) is the main event responsible
for irreversible disability accumulation in relapsing multiple sclerosis (MS). Objective To …
for irreversible disability accumulation in relapsing multiple sclerosis (MS). Objective To …
How patients with multiple sclerosis acquire disability
Patients with multiple sclerosis acquire disability either through relapse-associated
worsening (RAW) or progression independent of relapse activity (PIRA). This study …
worsening (RAW) or progression independent of relapse activity (PIRA). This study …
No evidence of disease activity (NEDA) analysis by epochs in patients with relapsing multiple sclerosis treated with ocrelizumab vs interferon beta-1a
Background No evidence of disease activity (NEDA; defined as no 12-week confirmed
disability progression, no protocol-defined relapses, no new/enlarging T2 lesions and no T1 …
disability progression, no protocol-defined relapses, no new/enlarging T2 lesions and no T1 …
Five years of ocrelizumab in relapsing multiple sclerosis: OPERA studies open-label extension
Objective To assess over 3 years of follow-up the effects of maintaining or switching to
ocrelizumab (OCR) therapy on clinical and MRI outcomes and safety measures in the open …
ocrelizumab (OCR) therapy on clinical and MRI outcomes and safety measures in the open …