[HTML][HTML] Overcoming therapeutic resistance in glioblastoma: the way forward

S Osuka, EG Van Meir - The Journal of clinical investigation, 2017 - Am Soc Clin Investig
Glioblastoma is the most common and lethal primary malignant brain tumor in adults.
Patients die from recurrent tumors that have become resistant to therapy. New strategies are …

[HTML][HTML] The importance of tumor stem cells in glioblastoma resistance to therapy

V Mattei, F Santilli, S Martellucci… - International journal of …, 2021 - mdpi.com
Glioblastoma (GBM) is known to be the most common and lethal primary malignant brain
tumor. Therapies against this neoplasia have a high percentage of failure, associated with …

Glioblastoma cancer stem cells: Biomarker and therapeutic advances

KB Pointer, PA Clark, M Zorniak, BM Alrfaei… - Neurochemistry …, 2014 - Elsevier
Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in
humans. It accounts for fifty-two percent of primary brain malignancies in the United States …

Glioblastoma cancer stem cell biology: Potential theranostic targets

F Sharifzad, S Ghavami, J Verdi, S Mardpour… - Drug Resistance …, 2019 - Elsevier
Glioblastoma multiforme (GBM) is among the most incurable cancers. GBMs survival rate
has not markedly improved, despite new radical surgery protocols, the introduction of new …

[HTML][HTML] Drug resistance in glioblastoma: are persisters the key to therapy?

L Oliver, L Lalier, C Salaud, D Heymann… - Cancer Drug …, 2020 - ncbi.nlm.nih.gov
Glioblastoma (GBM) represents the main form of brain tumors in adults, and one of the most
aggressive cancers overall. The treatment of GBM is a combination of surgery (when …

[HTML][HTML] Molecular mechanisms of treatment resistance in glioblastoma

A Ou, WKA Yung, N Majd - International journal of molecular sciences, 2020 - mdpi.com
Glioblastoma is the most common malignant primary brain tumor in adults and is almost
invariably fatal. Despite our growing understanding of the various mechanisms underlying …

[HTML][HTML] The many facets of therapy resistance and tumor recurrence in glioblastoma

A Goenka, D Tiek, X Song, T Huang, B Hu, SY Cheng - Cells, 2021 - mdpi.com
Glioblastoma (GBM) is the most lethal type of primary brain cancer. Standard care using
chemo-and radio-therapy modestly increases the overall survival of patients; however …

Cellular and molecular mechanisms of glioblastoma malignancy: Implications in resistance and therapeutic strategies

J Balça-Silva, D Matias, A do Carmo… - Seminars in cancer …, 2019 - Elsevier
Glioblastoma (GB) is the more frequent and malignant brain tumour. In spite of all efforts, the
median overall survival of GB patients remains approximately 15 months under therapy. The …

The role of glioma stem cells in chemotherapy resistance and glioblastoma multiforme recurrence

B Auffinger, D Spencer, P Pytel, AU Ahmed… - Expert review of …, 2015 - Taylor & Francis
Glioma stem cells (GSCs) constitute a slow-dividing, small population within a
heterogeneous glioblastoma. They are able to self-renew, recapitulate a whole tumor, and …

The evolution of the cancer stem cell state in glioblastoma: emerging insights into the next generation of functional interactions

K Mitchell, K Troike, DJ Silver, JD Lathia - Neuro-oncology, 2021 - academic.oup.com
Cellular heterogeneity is a hallmark of advanced cancers and has been ascribed in part to a
population of self-renewing, therapeutically resistant cancer stem cells (CSCs) …