Circular ecDNA promotes accessible chromatin and high oncogene expression
Oncogenes are commonly amplified on particles of extrachromosomal DNA (ecDNA) in
cancer,, but our understanding of the structure of ecDNA and its effect on gene regulation is …
cancer,, but our understanding of the structure of ecDNA and its effect on gene regulation is …
Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity
Human cells have twenty-three pairs of chromosomes. In cancer, however, genes can be
amplified in chromosomes or in circular extrachromosomal DNA (ecDNA), although the …
amplified in chromosomes or in circular extrachromosomal DNA (ecDNA), although the …
Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells
R Chamorro González, T Conrad, MC Stöber, R Xu… - Nature Genetics, 2023 - nature.com
Extrachromosomal DNAs (ecDNAs) are common in cancer, but many questions about their
origin, structural dynamics and impact on intratumor heterogeneity are still unresolved. Here …
origin, structural dynamics and impact on intratumor heterogeneity are still unresolved. Here …
Gene regulation on extrachromosomal DNA
Oncogene amplification on extrachromosomal DNA (ecDNA) is prevalent in human cancer
and is associated with poor outcomes. Clonal, megabase-sized circular ecDNAs in cancer …
and is associated with poor outcomes. Clonal, megabase-sized circular ecDNAs in cancer …
Live-cell imaging shows uneven segregation of extrachromosomal DNA elements and transcriptionally active extrachromosomal DNA hubs in cancer
Oncogenic extrachromosomal DNA elements (ecDNA) play an important role in tumor
evolution, but our understanding of ecDNA biology is limited. We determined the distribution …
evolution, but our understanding of ecDNA biology is limited. We determined the distribution …
Extrachromosomal DNA in cancer
V Bafna, PS Mischel - Annual review of genomics and human …, 2022 - annualreviews.org
In cancer, complex genome rearrangements and other structural alterations, including the
amplification of oncogenes on circular extrachromosomal DNA (ecDNA) elements, drive the …
amplification of oncogenes on circular extrachromosomal DNA (ecDNA) elements, drive the …
Extrachromosomal DNA: an emerging hallmark in human cancer
Human genes are arranged on 23 pairs of chromosomes, but in cancer, tumor-promoting
genes and regulatory elements can free themselves from chromosomes and relocate to …
genes and regulatory elements can free themselves from chromosomes and relocate to …
The genomic and spatial mobility of extrachromosomal DNA and its implications for cancer therapy
E van Leen, L Brückner, AG Henssen - Nature genetics, 2022 - nature.com
Extrachromosomal DNA (ecDNA) amplification has been observed in at least 30 different
cancer types and is associated with worse patient outcomes. This has been linked to …
cancer types and is associated with worse patient outcomes. This has been linked to …
ATAC-seq identifies thousands of extrachromosomal circular DNA in cancer and cell lines
Extrachromosomal circular DNAs (eccDNAs) are somatically mosaic and contribute to
intercellular heterogeneity in normal and tumor cells. Because short eccDNAs are poorly …
intercellular heterogeneity in normal and tumor cells. Because short eccDNAs are poorly …
[HTML][HTML] Oncogenic extrachromosomal DNA functions as mobile enhancers to globally amplify chromosomal transcription
Extrachromosomal, circular DNA (ecDNA) is emerging as a prevalent yet less characterized
oncogenic alteration in cancer genomes. We leverage ChIA-PET and ChIA-Drop chromatin …
oncogenic alteration in cancer genomes. We leverage ChIA-PET and ChIA-Drop chromatin …