The scRNA-seq expression profiling of the receptor ACE2 and the cellular protease TMPRSS2 reveals human organs susceptible to SARS-CoV-2 infection

J Qi, Y Zhou, J Hua, L Zhang, J Bian, B Liu… - International Journal of …, 2021 - mdpi.com
COVID-19 patients always develop multiple organ dysfunction syndromes other than lungs,
suggesting the novel virus SARS-CoV-2 also invades other organs. Therefore, studying the …

Multiple expression assessments of ACE2 and TMPRSS2 SARS-CoV-2 entry molecules in the urinary tract and their associations with clinical manifestations of COVID …

X Ren, S Wang, X Chen, X Wei, G Li… - Infection and Drug …, 2020 - Taylor & Francis
Background Since December 2019, the novel coronavirus, severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), first spread quickly in Wuhan, China, then globally …

[HTML][HTML] ACE2, TMPRSS2 distribution and extrapulmonary organ injury in patients with COVID-19

M Dong, J Zhang, X Ma, J Tan, L Chen, S Liu… - Biomedicine & …, 2020 - Elsevier
At the end of 2019, the coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in China. Currently, it is …

Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection

X Zou, K Chen, J Zou, P Han, J Hao, Z Han - Frontiers of medicine, 2020 - Springer
It has been known that, the novel coronavirus, 2019-nCoV, which is considered similar to
SARS-CoV, invades human cells via the receptor angiotensin converting enzyme II (ACE2) …

scRNA-seq profiling of human testes reveals the presence of the ACE2 receptor, a target for SARS-CoV-2 infection in spermatogonia, Leydig and Sertoli cells

Z Wang, X Xu - Cells, 2020 - mdpi.com
In December 2019, a novel coronavirus (SARS-CoV-2) was identified in COVID-19 patients
in Wuhan, Hubei Province, China. SARS-CoV-2 shares both high sequence similarity and …

Digestive system is a potential route of COVID-19: an analysis of single-cell coexpression pattern of key proteins in viral entry process

H Zhang, Z Kang, H Gong, D Xu, J Wang, Z Li, Z Li… - Gut, 2020 - gut.bmj.com
Objective Since December 2019, a newly identified coronavirus (severe acute respiratory
syndrome coronavirus (SARS-CoV-2)) has caused outbreaks of pneumonia in Wuhan …

Systemic analysis of tissue cells potentially vulnerable to SARS-CoV-2 infection by the protein-proofed single-cell RNA profiling of ACE2, TMPRSS2 and Furin …

L Zhou, Z Niu, X Jiang, Z Zhang, Y Zheng, Z Wang… - BioRxiv, 2020 - biorxiv.org
Single-cell RNA profiling of ACE2, the SARS-CoV-2 receptor, had proposed multiple tissue
cells as the potential targets of SARS-CoV-2, the novel coronavirus causing the COVID-19 …

ACE2 expression in kidney and testis may cause kidney and testis infection in COVID-19 patients

C Fan, W Lu, K Li, Y Ding, J Wang - Frontiers in medicine, 2021 - frontiersin.org
In December 2019, a new type of pneumonia caused by SARS-Cov-2 (COVID-19) occurred
in Wuhan and has been discovered in many countries around the world. ACE2 (angiotensin …

Age and gender differences in ACE2 and TMPRSS2 expressions in oral epithelial cells

J Peng, J Sun, J Zhao, X Deng, F Guo… - Journal of translational …, 2021 - Springer
Abstract Background SARS-CoV-2, which has brought a huge negative impact on the world
since the end of 2019, is reported to invade cells using the spike (S) protein to bind to …

Systematic analysis of ACE2 and TMPRSS2 expression in salivary glands reveals underlying transmission mechanism caused by SARS‐CoV‐2

J Song, Y Li, X Huang, Z Chen, Y Li… - Journal of medical …, 2020 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19) is a global pandemic that has caused
severe health threats and fatalities in almost all communities. Studies have detected severe …