[HTML][HTML] The medial septum as a potential target for treating brain disorders associated with oscillopathies

Y Takeuchi, AJ Nagy, L Barcsai, Q Li… - Frontiers in Neural …, 2021 - frontiersin.org
The medial septum (MS), as part of the basal forebrain, supports many physiological
functions, from sensorimotor integration to cognition. With often reciprocal connections with …

Evidence supporting deep brain stimulation of the medial septum in the treatment of temporal lobe epilepsy

ER Cole, DP Grogan, NG Laxpati, AM Fernandez… - …, 2022 - Wiley Online Library
Electrical brain stimulation has become an essential treatment option for more than one third
of epilepsy patients who are resistant to pharmacological therapy and are not candidates for …

Closed-loop stimulation of the medial septum terminates epileptic seizures

Y Takeuchi, M Harangozó, L Pedraza, T Földi, G Kozák… - Brain, 2021 - academic.oup.com
Temporal lobe epilepsy with distributed hippocampal seizure foci is often intractable and its
secondary generalization might lead to sudden death. Early termination through spatially …

Differential and complementary roles of medial and lateral septum in the orchestration of limbic oscillations and signal integration

M Tsanov - European Journal of Neuroscience, 2018 - Wiley Online Library
Anatomical differences between the medial and lateral septum have associated these nuclei
with dissimilar functional roles and behaviours. While the medial septum has been …

The medial septum: node of the ascending brainstem hippocampal synchronizing pathways

BH Bland - The behavioral neuroscience of the septal region, 2000 - Springer
The study of electroencephalographic (EEG)(field) activities indigenous to the hippocampal
formation (HPC) has proven to be a fruitful approach, based on the assumption that they …

Stimulation of the medial septum should benefit patients with temporal lobe epilepsy

RS Fisher - Medical hypotheses, 2015 - Elsevier
Electrical stimulation of the septal nuclei via deep brain stimulating electrodes is proposed
as a potentially beneficial therapy for medication-resistant temporal lobe epilepsy. In a …

[HTML][HTML] Medial septal stimulation increases seizure threshold and improves cognition in epileptic rats

A Izadi, A Pevzner, DJ Lee, AD Ekstrom, K Shahlaie… - Brain Stimulation, 2019 - Elsevier
Background Temporal lobe epilepsy is most prevalent among focal epilepsies, and nearly
one-third of patients are refractory to pharmacological intervention. Persistent cognitive and …

Oscillotherapeutics–Time-targeted interventions in epilepsy and beyond

Y Takeuchi, A Berényi - Neuroscience Research, 2020 - Elsevier
Oscillatory brain activities support many physiological functions from motor control to
cognition. Disruptions of the normal oscillatory brain activities are commonly observed in …

Deep brain stimulation in the medial septum attenuates temporal lobe epilepsy via entrainment of hippocampal theta rhythm

Y Wang, Y Shen, X Cai, J Yu, C Chen… - CNS neuroscience & …, 2021 - Wiley Online Library
Aims Temporal lobe epilepsy (TLE), often associated with cognitive impairment, is one of the
most common types of medically refractory epilepsy. Deep brain stimulation (DBS) shows …

Clinically indicated electrical stimulation strategies to treat patients with medically refractory epilepsy

A Izadi, K Ondek, A Schedlbauer, I Keselman… - Epilepsia …, 2018 - Wiley Online Library
Focal epilepsies represent approximately half of all diagnoses, and more than one‐third of
these patients are refractory to pharmacologic treatment. Although resection can result in …