Aldose reductase (AR) is an aldo-keto reductase that catalyzes the first step in the polyol
pathway which converts glucose to sorbitol. Under normal glucose homeostasis the pathway …

Aldose reductase [ALR2; EC 1.1. 1.21], a key enzyme of polyol pathway, catalyzes NADPH-
dependent reduction of glucose to sorbitol (Sorbitol pathway), and an excessive …

Aldose reductase (AR), that catalyzes the rate limiting step of the polyol pathway of glucose
metabolism, besides reducing glucose to sorbitol, reduces a number of lipid peroxidation …

Aldose reductase (AR) is widely expressed aldehyde-metabolizing enzyme. The reduction
of glucose by the AR-catalyzed polyol pathway has been linked to the development of …

Aldose reductase ([EC1. 1.1. 21]: AR) acts on the first step of the polyol metabolic pathway to
catalyze the reduction of glucose to sorbitol with NADPH as a coenzyme. Hyperactivity of the …

Aldose reductase, classified within the aldo-keto reductase family as AKR1B1, is an NADPH
dependent enzyme that catalyzes the reduction of hydrophilic as well as hydrophobic …

Diabetes mellitus occurrence has been associated to the modification of the physiological
levels of glucose and is often accompanied by several long-term complications, namely …

In the past years aldose reductase (AKR1B1; AR) is thought to be involved in the
pathogenesis of secondary diabetic complications such as retinopathy, neuropathy …

Hyperglycemia and reduced insulin actions affect many biological processes. One theory is
that aberrant metabolism of glucose via several pathways including the polyol pathway …

Diabetes mellitus, a disorder of metabolism, results in the elevation of glucose level in the
blood. In this hyperglycaemic condition, aldose reductase overexpresses and leads to …