What is currently known about the role of CXCL10 in SARS-CoV-2 infection?

M Gudowska-Sawczuk, B Mroczko - International Journal of Molecular …, 2022 - mdpi.com
Dysregulation of the immune response plays an important role in the progression of SARS-
CoV-2 infection. A “cytokine storm”, which is a phenomenon associated with uncontrolled …

[PDF][PDF] CXCL10 an important chemokine associated with cytokine storm in COVID-19 infected patients.

N Zhang, YD Zhao, XM Wang - European Review for Medical & …, 2020 - europeanreview.org
OBJECTIVE: The specific mechanism of cytokine storm in COVID-19 infected patients is not
clear. This study aims to identify the key genes that cause cytokine storm in COVID-19 …

CXCL8, CCL2, and CMV seropositivity as new prognostic factors for a severe COVID-19 course

E Pius-Sadowska, A Niedźwiedź, P Kulig… - International Journal of …, 2022 - mdpi.com
The exact pathophysiology of severe COVID-19 is not entirely elucidated, but it has been
established that hyperinflammatory responses and cytokine storms play important roles. The …

CXCL10 levels at hospital admission predict COVID-19 outcome: hierarchical assessment of 53 putative inflammatory biomarkers in an observational study

NI Lorè, R De Lorenzo, PMV Rancoita, F Cugnata… - Molecular …, 2021 - Springer
Background Host inflammation contributes to determine whether SARS-CoV-2 infection
causes mild or life-threatening disease. Tools are needed for early risk assessment …

Association of CXCR6 with COVID-19 severity: delineating the host genetic factors in transcriptomic regulation

Y Dai, J Wang, HH Jeong, W Chen, P Jia, Z Zhao - Human genetics, 2021 - Springer
Abstract The coronavirus disease 2019 (COVID-19) is an infectious disease that mainly
affects the host respiratory system with~ 80% asymptomatic or mild cases and~ 5% severe …

Interplay of antibody and cytokine production reveals CXCL13 as a potential novel biomarker of lethal SARS-CoV-2 infection

AM Horspool, T Kieffer, BP Russ, MA DeJong, MA Wolf… - Msphere, 2021 - Am Soc Microbiol
The SARS-CoV-2 pandemic is impacting the global population. This study was designed to
assess the interplay of antibodies with the cytokine response in SARS-CoV-2 patients. We …

Serum CCL17 level becomes a predictive marker to distinguish between mild/moderate and severe/critical disease in patients with COVID-19

M Sugiyama, N Kinoshita, S Ide, H Nomoto… - Gene, 2021 - Elsevier
Abstract COVID-19, a novel coronavirus-related illness, has spread worldwide. Patients with
apparently mild/moderate symptoms can suddenly develop severe pneumonia. Therefore …

The pro-inflammatory chemokines CXCL9, CXCL10 and CXCL11 are upregulated following SARS-CoV-2 infection in an AKT-dependent manner

V Callahan, S Hawks, MA Crawford, CW Lehman… - Viruses, 2021 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible
RNA virus that is the causative agent of the Coronavirus disease 2019 (COVID-19) …

Role of CCL2/CCR2 axis in the pathogenesis of COVID-19 and possible Treatments: All options on the Table

M Ranjbar, A Rahimi, Z Baghernejadan… - International …, 2022 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is cause of the novel
coronavirus disease (COVID-19). In the last two years, SARS-CoV-2 has infected millions of …

[HTML][HTML] Blocking inflammation on the way: Rationale for CXCR2 antagonists for the treatment of COVID-19

LM Koenig, DFR Boehmer, P Metzger… - Journal of Experimental …, 2020 - rupress.org
An exacerbated and unbalanced immune response may account for the severity of COVID-
19, the disease caused by the novel severe acute respiratory syndrome (SARS) coronavirus …