Background GBA1 variants are among the most common genetic risk factors for Parkinson's
disease (PD). GBA1 variants can be classified into three categories based on their role in …

Background The most common genetic risk factor for Parkinson's disease known is a
damaging variant in the GBA1 gene. The entire GBA1 gene has rarely been studied in a …

Background Variants in GBA are the most common genetic risk factor for Parkinson's
disease (PD). The impact of different variants on the PD clinical spectrum is still unclear …

Background Parkinson's disease (PD) patients with GBA mutations show an earlier age at
onset and more severe non‐motor symptoms compared with PD patients without GBA …

Background Alterations in the GBA gene (NM_000157. 3) are the most important genetic risk
factor for Parkinson's disease (PD). Biallelic GBA mutations cause the lysosomal storage …

Background Loss‐of‐function mutations in the GBA gene are associated with more severe
cognitive impairment in PD, but the nature of these deficits is not well understood and …

Background Five to 25% of patients with PD carry glucocerebrosidase gene mutations, and
10% to 30% of glucocerebrosidase carriers will develop PD by age 80. Stratification of PD …

Background Mutations in the GBA gene cause Gaucher's disease (GD) and constitute the
most frequent genetic risk factor for idiopathic Parkinson's disease (iPD). Nonmanifesting …

GBA1 variants are important risk factors for Parkinson's disease (PD). Most studies
assessing GBA1-related PD risk have been performed in European-derived populations …

Background To date, variants in the GBA gene represent the most frequent large‐effect
genetic factor associated with Parkinson's disease (PD). However, the reason why …