Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex

SL Valk, T Xu, C Paquola, B Park… - Nature …, 2022 - nature.com
Brain structure scaffolds intrinsic function, supporting cognition and ultimately behavioral
flexibility. However, it remains unclear how a static, genetically controlled architecture …

[HTML][HTML] Cross-species functional alignment reveals evolutionary hierarchy within the connectome

T Xu, KH Nenning, E Schwartz, SJ Hong, JT Vogelstein… - Neuroimage, 2020 - Elsevier
Evolution provides an important window into how cortical organization shapes function and
vice versa. The complex mosaic of changes in brain morphology and functional organization …

Shaping brain structure: Genetic and phylogenetic axes of macroscale organization of cortical thickness

SL Valk, T Xu, DS Margulies, SK Masouleh… - Science …, 2020 - science.org
The topology of the cerebral cortex has been proposed to provide an important source of
constraint for the organization of cognition. In a sample of twins (n= 1113), we determined …

Microstructural and functional gradients are increasingly dissociated in transmodal cortices

C Paquola, R Vos De Wael, K Wagstyl… - PLoS …, 2019 - journals.plos.org
While the role of cortical microstructure in organising neural function is well established, it
remains unclear how structural constraints can give rise to more flexible elements of …

Evolutionary expansion of connectivity between multimodal association areas in the human brain compared with chimpanzees

DJ Ardesch, LH Scholtens, L Li… - Proceedings of the …, 2019 - National Acad Sciences
The development of complex cognitive functions during human evolution coincides with
pronounced encephalization and expansion of white matter, the brain's infrastructure for …

Structural connectivity gradients of the temporal lobe serve as multiscale axes of brain organization and cortical evolution

R Vos de Wael, J Royer, S Tavakol, Y Wang… - Cerebral …, 2021 - academic.oup.com
The temporal lobe is implicated in higher cognitive processes and is one of the regions that
underwent substantial reorganization during primate evolution. Its functions are instantiated …

Decoupling of brain function from structure reveals regional behavioral specialization in humans

MG Preti, D Van De Ville - Nature communications, 2019 - nature.com
The brain is an assembly of neuronal populations interconnected by structural pathways.
Brain activity is expressed on and constrained by this substrate. Therefore, statistical …

Individual variability in functional connectivity architecture of the human brain

S Mueller, D Wang, MD Fox, BTT Yeo, J Sepulcre… - Neuron, 2013 - cell.com
The fact that people think or behave differently from one another is rooted in individual
differences in brain anatomy and connectivity. Here, we used repeated-measurement …

Heritability of individualized cortical network topography

KM Anderson, T Ge, R Kong… - Proceedings of the …, 2021 - National Acad Sciences
Human cortex is patterned by a complex and interdigitated web of large-scale functional
networks. Recent methodological breakthroughs reveal variation in the size, shape, and …

Comparative analysis of the macroscale structural connectivity in the macaque and human brain

A Goulas, M Bastiani, G Bezgin… - PLoS computational …, 2014 - journals.plos.org
The macaque brain serves as a model for the human brain, but its suitability is challenged
by unique human features, including connectivity reconfigurations, which emerged during …