Diabetic retinopathy (DR) has long been recognized as a microvasculopathy, but retinal
diabetic neuropathy (RDN), characterized by inner retinal neurodegeneration, also occurs in …

Purpose To review the evidence supporting diabetic retinal neurodegeneration (DRN) as a
form of diabetic retinopathy. Method Review of literature. Results DRN is recognized to be a …

Since 1875, controversy has ensued over whether ocular diabetic complications are
primarily vasculopathic or neuropathic in nature. Here, we discuss the historical context by …

Abstract Purpose of Review Diabetic retinopathy (DR), the leading cause of blindness in
working-aged adults, remains clinically defined and staged by its vascular manifestations …

purpose. Lack of information about the development of diabetic retinopathy in mice has
greatly hindered the use of genetic mouse models for the study of disease mechanisms and …

The complex pathology of diabetic retinopathy (DR) affects both vascular and neural tissue.
The characteristics of neurodegeneration are well-described in animal models but have …

Normal vision depends on the normal function of retinal neurons, so vision loss in diabetes
must ultimately be explained in terms of altered neuronal function. However, to date …

Vision loss in diabetic retinopathy (DR) is ascribed primarily to retinal vascular abnormalities—
including hyperpermeability, hypoperfusion, and neoangiogenesis—that eventually lead to …

Purpose: To determine whether type 1 diabetes (T1DM) in children with a mean age of
12.21±3.04 years affects the retinal nerve fiber layer (RNFL) and ganglion cell complex …

The concept of diabetic retinopathy as a microvascular disease has evolved, in that it is now
considered a more complex diabetic complication in which neurodegeneration plays a …