[HTML][HTML] Therapeutic effects of melatonin on ocular diseases: knowledge map and perspective

H Yu, Q Wang, W Wu, W Zeng, Y Feng - Frontiers in Pharmacology, 2021 - frontiersin.org
Melatonin plays a critical role in the pathophysiological process including circadian rhythm,
apoptosis, and oxidative stress. It can be synthesized in ocular tissues, and its receptors are …

Melatonin: implications for ocular disease and therapeutic potential

L Scuderi, S Davinelli, CM Iodice… - Current …, 2019 - ingentaconnect.com
Melatonin, an indoleamine secreted mainly by the pineal gland, is known to modulate a
wide range of circadian functions. However, this neurohormone is also synthesized within …

[HTML][HTML] Melatonin: Unveiling the Functions and Implications in Ocular Health

J Zhang, H Zhou, Y Cai, S Yoshida, Y Li… - Pharmacological …, 2024 - Elsevier
Melatonin, a versatile hormone produced by the pineal gland, has garnered considerable
scientific interest due to its diverse functions. In the eye, melatonin regulates a variety of key …

[HTML][HTML] The therapeutic trip of melatonin eye drops: from the ocular surface to the retina

D Rusciano, C Russo - Pharmaceuticals, 2024 - mdpi.com
Melatonin is a ubiquitous molecule found in living organisms, ranging from bacteria to plants
and mammals. It possesses various properties, partly due to its robust antioxidant nature …

[HTML][HTML] Light, dark, and melatonin: emerging evidence for the importance of melatonin in ocular physiology

R Brennan, JE Jan, CJ Lyons - Eye, 2007 - nature.com
Melatonin is a hormone, which is mainly produced by the pineal gland, a vestigial eye.
Rather than the rods and cones, it is a newly discovered subgroup of photosensitive retinal …

[HTML][HTML] A Clinical, Pharmacological, and Formulation Evaluation of Melatonin in the Treatment of Ocular Disorders—A Systematic Review

A Romeo, A Kazsoki, T Musumeci, R Zelkó - International Journal of …, 2024 - mdpi.com
Melatonin's cytoprotective properties may have therapeutic implications in treating ocular
diseases like glaucoma and age-related macular degeneration. Literature data suggest that …

Melatonin: an underappreciated player in retinal physiology and pathophysiology

G Tosini, K Baba, CK Hwang, PM Iuvone - Experimental eye research, 2012 - Elsevier
In the vertebrate retina, melatonin is synthesized by the photoreceptors with high levels of
melatonin at night and lower levels during the day. Melatonin exerts its influence by …

Ocular disorders and the utility of animal models in the discovery of melatoninergic drugs with therapeutic potential

A Crooke, F Huete-Toral… - Expert Opinion on …, 2012 - Taylor & Francis
Introduction: The pineal indole-derived hormone melatonin is a modulator of circadian and
seasonal rhythms with an important role in ocular health and disease. This could be due to …

Role of melatonin in the eye and ocular dysfunctions

PO Lundmark, SR Pandi-Perumal, V Srinivasan… - Visual …, 2006 - cambridge.org
Melatonin is a ubiquitous molecule and widely distributed in nature, with functional activity
occurring in unicellular organisms, plants, fungi, and animals. Several studies have …

Melatonin and the control of intraocular pressure

HA Alkozi, G Navarro, R Franco, J Pintor - Progress in retinal and eye …, 2020 - Elsevier
Melatonin is not only synthesized by the pineal gland but by several ocular structures. This
natural indoleamine is of great importance for regulating several eye processes, among …