Reactive oxygen species (ROS) operate as key regulators of cellular homeostasis within a
physiological range of concentrations, yet they turn into cytotoxic entities when their levels …

Autophagy is one of the major degradative mechanisms that can eliminate excessive
nutrients, toxic protein aggregates, damaged organelles and invading microorganisms. In …

Obesity poses a severe threat to human health, including the increased prevalence of
hypertension, insulin resistance, diabetes mellitus, cancer, inflammation, sleep apnoea and …

Autophagy, lipophagy, and mitophagy are considered to be the major recycling processes
for protein aggregates, excess fat, and damaged mitochondria in adipose tissues in …

Despite growing interest in the relationship between autophagy and systemic metabolism,
how global changes in autophagy affect metabolism remains unclear. Here we show that …

Autophagy is a cellular pathway crucial for development, differentiation, survival and
homeostasis. Autophagy can provide protection against aging and a number of pathologies …

Significance: Alterations in adipose tissue function have profound consequences on whole
body energy homeostasis because this tissue is central for fat accumulation, energy …

The inflammatory response is an energy-intensive process. Consequently, metabolism is
closely associated with immune function. The autophagy machinery plays a role in …

Reactive oxygen species (ROS), chemically reactive molecules containing oxygen, can form
as a natural byproduct of the normal metabolism of oxygen and also have their crucial roles …

Sarcopenic obesity (SOB), which is closely related to being elderly as a feature of aging, is
recently gaining attention because it is associated with many other age-related diseases that …