Recent evidence proposed that the severity of Coronavirus disease 2019 (COVID-19)
patients is a consequence of cytokine storm, characterized by increased IL-1β, IL-6, IL-18 …

Cytokine signaling, especially interferon (IFN) signaling is closely linked to several aspects
of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. During initial …

As the incidence of COVID-19 increases with time, more and more efforts are made to pave
a way out for the therapeutic strategies to deal with the disease progression. Inflammation …

Recent advances in the pathophysiologic understanding of the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection has indicated that patients with severe …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic continues to
spread globally. The rapid dispersion of coronavirus disease 2019 (COVID-19) caused by …

Severe cases of COVID-19 are characterized by hyperinflammation induced by cytokine
storm, ARDS leading to multiorgan failure and death. JAK-STAT signaling has been …

Ruxolitinib is the first approved JAK1 and JAK2 inhibitor, and is known to interfere with the
JAK/STAT signaling pathway, one of the critical cellular signaling pathways involved in the …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has become a
serious public health threat to the whole world, and the number of infected is still rising …

Background In inflamed tissue, immune cells are accumulated, and various intercellular
signals are involved in the pathogenesis. Janus kinases (JAKs) are typical tyrosine kinases …

Background Currently, JAK-inhibitors are repurposed for therapy of Covid-19 because of
their ability in restraining immune response, yet the corroboration regarding their advantage …