Nephrotoxicity is a major side effect of cisplatin treatment of solid tumors in the clinical
setting. Long-term low-dose cisplatin administration causes renal fibrosis and inflammation …

Cisplatin is a well-known chemotherapeutic drug applied for the treatment of numerous
human cancers. However, the use of cisplatin in clinic is limited by certain serious side …

Cisplatin-induced acute kidney injury (CIAKI) is a common complication in patients receiving
cisplatin-based chemotherapy. But the effective therapies for CIAKI are not available …

Cisplatin is a highly effective anti-cancer chemotherapeutic agent; however, its clinical use is
severely limited by serious side effects, of which nephrotoxicity is the most important. In this …

Background Although cisplatin (DDP) is an important clinical anti-tumor drug, its use is
limited by its nephrotoxicity. How to avoid the renal injury incurred by platinum drugs and …

Background Celastrol is an active ingredient of Chinese medicine Tripterygium wilfordii
which is clinically used to treat the immune diseases. Currently, celastrol is documented as a …

Cisplatin chemotherapy often causes acute kidney injury in cancer patients. Icariin is a
bioactive flavonoid, which has renal protection and anti-inflammation effects. This study …

Renal fibrosis is a typical pathological change in chronic kidney disease (CKD). Epithelial-
mesenchymal transition (EMT) is the predominant stage. Activation of macroautophagy …

The main lesion of cisplatin nephrotoxicity is damage to proximal tubular cells due to
increased apoptosis via the mitochondrial and death receptor pathways, which may be …

Introduction: Acute kidney injury (AKI) is at a high prevalence in hospitalized patients,
especially in those receiving chemotherapy. Cisplatin is the most widely used chemotherapy …