Fungi actively alter their metabolic and synthetic pathways to cope with changing
environmental conditions. The mitochondrial pyruvate carrier (MPC) plays a vital role in …

Nitrogen limitation has been widely reported to affect the growth and development of fungi,
and the transcription factor GCN4 (general control nonderepressible 4) is involved in …

Fungi utilize a wide range of nitrogen to adapt their metabolism. The transcription factor
GCN4 has a pivotal role in nitrogen metabolism. However, the mechanism by which GCN4 …

Mitochondrial pyruvate carriers (MPCs), located in the inner membrane of mitochondria, are
essential carriers for pyruvate to enter mitochondria. MPCs regulate a wide range of …

Cellulose is a by‐product of agricultural production and an abundant waste. As a carbon
source, cellulose can be degraded and utilized by fungi. Carbon sources, which act as …

Nicotinamide adenine dinucleotide (NAD+) is an important intracellular metabolite that is
involved in different cel1lular processes. Glnmnat is the key enzyme that can affect …

Glutamine synthetase (GS), a central nitrogen metabolic enzyme, plays important roles in
the nitrogen regulation network and secondary metabolism in fungi. However, the …

Nitrogen metabolism repression (NMR) has been well studied in filamentous fungi, but the
molecular mechanism of its effects on fungal secondary metabolism has been generally …

Central carbon metabolism describes the integration of transport pathway of main carbon
sources inside the cell. Nitrogen (N) limitation is a favorable approach to stimulate ganoderic …

Water stress affects both the growth and development of filamentous fungi; however, the
mechanisms underlying their response to water stress remain unclear. In this study, water …