Carbocyclic nucleoside analogues have a distinguished history as anti-infectious agents,
including key antiviral agents. Toxicity was initially a concern but this was reduced by the …

Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial
therapies. Recent results from our laboratories from two structurally related scaffolds have …

Chagas disease and leishmaniasis are two poverty-related neglected tropical diseases that
cause high mortality and morbidity. Current treatments suffer from severe limitations and …

Chagas disease and visceral leishmaniasis are two neglected tropical diseases responsible
for numerous deaths around the world. For both, current treatments are largely inadequate …

Fifteen purine nucleosides and their O-acetylated ester derivatives were examined for in
vitro antitrypanosomal activity against the LAB 110 EATRO isolate of Trypanosoma brucei …

The following structurally diverse 5-substituted-2′-deoxyuridine nucleosides displayed
potent in vitro antileishmanial activity: 5-formyl, 5-(2, 2,-dicyanovinyl)-, 5-(2-cyano-2 …

We report herein the synthesis and the in vitro antileishmanial evaluation of 5-substituted-
2′-deoxyuridine nucleosides. The most active compound against Leishmania donovani …

Chagas disease is the leading cause of cardiac-related mortality in Latin American countries
where it is endemic. Trypanosoma cruzi, the disease-causing pathogen, is unable to …

Chagas disease is a tropical infectious disease resulting in progressive organ‐damage and
currently lacks efficient treatment and vaccine options. The causative pathogen …

Human African trypanosomiasis is a neglected tropical disease caused by Trypanosoma
brucei parasites. These protists are unable to produce the purine ring, making them …