Mann and Zhang et al. developed a robust ex vivo slice culture platform consisting of
resected patient high-and low-grade glioma tissue engrafted onto rat organotypic brain …

Brain tumors are a major cause of cancer-related morbidity and mortality. Developing new
therapeutics for these cancers is difficult, as many of these tumors are not easily grown in …

Identifying drugs for the treatment of glioblastoma (GBM), a rapidly fatal disease, has been
challenging. Most screening efforts have been conducted with immortalized cell lines grown …

In vitro drug sensitivity screens are important tools in the discovery of anti-cancer drug
combination therapies. Typically, these in vitro drug screens are performed on cells grown in …

Three dimensional models of cell culture enables researchers to recreate aspects of tumour
biology not replicated by traditional two dimensional techniques. Here we describe a …

Glioblastoma (GBM) is the most aggressive primary brain tumor in adults. Designing
effective individualized therapies for GBM requires quality fresh tissue specimens, and a …

Glioblastomas, the most common and aggressive form of astrocytoma, are refractory to
therapy, and molecularly heterogeneous. The ability to establish cell cultures that preserve …

Glioblastoma (GBM) is the most aggressive primary brain cancer with an average survival
time after diagnosis of only 12–14 months, with few (< 5%) long-term survivors. A growing …

Functional precision medicine platforms are emerging as promising strategies to improve
pre-clinical drug testing and guide clinical decisions. We have developed an organotypic …

Diffusely infiltrating gliomas (DIGs) are difficult to completely resect and are associated with
a high rate of tumor relapse and progression from low-to high-grade glioma. In particular …