Chromatin reorganization is governed by multiple post-translational modifications of
chromosomal proteins and DNA,. These histone modifications are reversible, dynamic …

The monosaccharide, β-N-acetylglucosamine (GlcNAc), can be added to the hydroxyl group
of either serines or threonines to generate an O-linked β-N-acetylglucosamine (O-GlcNAc) …

Ubiquitylation of histone H2B at lysine residue 120 (H2BK120ub) is a prominent histone
posttranslational modification (PTM) associated with the actively transcribed genome …

Histone modifications have emerged as important regulators of transcription,. Histone H2B
monoubiquitination has also been implicated in transcription,; however, better …

DNA double-strand breaks (DSBs) are highly cytotoxic DNA lesions that trigger non-
proteolytic ubiquitylation of adjacent chromatin areas to generate binding sites for DNA …

Mitosis must faithfully divide the genome such that each progeny inherits the same genetic
material. DNA condensation is crucial in ensuring that chromosomes are correctly attached …

Dynamic posttranslational modification of serine and threonine residues of
nucleocytoplasmic proteins by β-N-acetylglucosamine (O-GlcNAc) is a regulator of cellular …

In eukaryotes, the DNA of the genome is packaged with histone proteins to form
nucleosomal filaments, which are, in turn, folded into a series of less well understood …

Abstract 53BP1 (also called TP53BP1) is a chromatin-associated factor that promotes
immunoglobulin class switching and DNA double-strand-break (DSB) repair by non …

Nucleocytoplasmic glycosylation of proteins with O-linked N-acetylglucosamine residues (O-
GlcNAc) is recognized as a conserved post-translational modification found in all …